IL-18 and IL-18 binding protein levels in patients with dengue virus infection

被引：0

作者：

Chirathaworn, Chintana ^{[1
]}

Poovorawan, Yong ^{[2
]}

Vuthitanachot, Viboonsak

机构：

[1] Chulalongkorn Univ, Fac Med, Dept Microbiol, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Fac Med, Dept Pediat, Bangkok 10330, Thailand

来源：

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2010年 / 3卷 / 10期

关键词：

Dengue virus; IL-18; IL-18BP; HEMORRHAGIC-FEVER; ENDOTHELIAL-CELLS; CYTOKINE; INTERLEUKIN-18; ACTIVATION;

D O I：

10.1016/S1995-7645(10)60195-2

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: To determine the levels of IL-18 and IL-18 binding protein(BP) in patients with dengue virus infection. Methods: Acute and convalescent sera were collected from each patient. :Control group was sera from blood donors. The levels of both IL-18 and IL-18BP were measured by ELISA assays. Results: It was shown that IL-18 and IL-18BP levels were significantly higher in patients when compared with controls. In addition, the level of IL-18BP was lower in convalescent than in acute sera. Conclusions: These data suggest that both IL-18 and IL-18BP production was induced following dengue virus infection. Investigating the regulation of IL-18 by its natural regulator could lead to further understanding of the immune response or immunopathogenesis following dengue virus infection.

引用

页码：812 / 814

页数：3

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