Ratios between the Levels of IL-18, Free IL-18, and IL-1β-Binding Protein Depending on the Severity and Outcome of COVID-19

被引：1
|
作者：
Korotaeva, A. A. [1 ]
Samoilova, E. V. [1 ]
Pogosova, N. V. [1 ]
Fesenko, A. G. [1 ]
Evchenko, S. V. [1 ]
Paleev, F. N. [1 ]
机构：
[1] Minist Hlth Russian Federat, E I Chazov Natl Med Res Ctr Cardiol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2024年 / 176卷 / 04期
关键词：
interleukin-18; interleukin-18-binding protein; inflammation; COVID-19; lung injury; FREE INTERLEUKIN-18; DISEASE; SERUM;
D O I：
10.1007/s10517-024-06039-6
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In 89 patients with COVID-19, the ratios between IL-18, free IL-18, and IL-18-binding protein (IL-18BP) were analyzed depending on severity and outcome of the disease. At admission to the hospital, the levels of IL-18 and free IL-18 were significantly higher than 3 months after discharge from the hospital, the levels IL-18BP of being almost the same. In patients with more severe lung injury (computed tomography data), the levels of IL-18 and free IL-18 were higher and IL-18BP levels were lower than in patients with mild and moderate COVID-19. Three months after discharge from the hospital, no differences between these parameters were found. In 9 patients who died in the hospital, free IL-18 levels were significantly higher and IL-18BP levels were lower than in survivors. Thus, high levels of bioactive free IL-18 in combination with low levels of IL-18BP can be indicative of severe inflammatory phase of COVID-19 and the risk of worse clinical outcomes.
引用
收藏
页码：423 / 427
页数：5
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