On-Site, On-Demand 3D-Printed Nasopharyngeal Swabs to Improve the Access of Coronavirus Disease-19 Testing

被引：3

作者：

Song, Jiaxi ^{[1
]}

Korunes-Miller, Jeremy ^{[1
]}

Banerji, Rohin ^{[1
]}

Wu, Yuanqiao ^{[2
]}

Fazeli, Shoreh ^{[3
]}

Zheng, Hanqiao ^{[3
]}

Orr, Beverley ^{[4
]}

Morgan, Elise ^{[1
,2
]}

Andry, Christopher ^{[3
]}

Henderson, Joel ^{[3
]}

Miller, Nancy S. ^{[3
,4
]}

White, Alice ^{[1
,2
]}

Grinstaff, Mark W. ^{[1
,5
,6
]}

机构：

[1] Boston Univ, Dept Biomed Engn, Boston Med Ctr, Boston, MA 02215 USA

[2] Boston Univ, Dept Mech Engn, Boston Med Ctr, Boston, MA 02215 USA

[3] Boston Univ, Dept Pathol & Lab Med, Boston Med Ctr, Boston, MA 02215 USA

[4] Boston Univ, Clin Microbiol & Mol Diagnost, Boston Med Ctr, Boston, MA 02215 USA

[5] Boston Univ, Dept Chem, Boston Med Ctr, 590 Commonwealth Ave, Boston, MA 02215 USA

[6] Boston Univ, Dept Med, Boston Med Ctr, Boston, MA 02215 USA

来源：

GLOBAL CHALLENGES | 2021年 / 5卷 / 11期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

3D printing; coronavirus disease-19; nasopharyngeal swab; SARS-CoV-2;

D O I：

10.1002/gch2.202100039

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Diagnostic testing that facilitates containment, surveillance, and treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or future respiratory viruses, depends on a sample collection device that efficiently collects nasopharyngeal tissue and that can be manufactured on site when an outbreak or public health emergency is declared by a government. Here two novel stereolithography-based three-dimensional (3D)-printed nasopharyngeal swabs are reported which are made using a biocompatible and sterilizable photo-resist. Such swabs are readily manufactured on-site and on-demand to ensure availability, if supply chain shortages emerge. Additionally, the 3D-printed swabs easily adapt to current workflow and testing procedures in hospital clinical laboratories to allow for effortless scaling up of test kits. Finally, the 3D-printed nasopharyngeal swabs demonstrate concordant SARS-CoV-2 testing results between the 3D-printed swabs and the COPAN commercial swabs, and enable detection of SARS-CoV-2 in clinical samples obtained from autopsies.

引用

页数：7

共 49 条

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INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2020, 49 (12) : 1661 - 1661
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