Brain barriers: Crosstalk between complex tight junctions and adherens junctions

被引：379
|
作者：
Tietz, Silvia [1 ]
Engelhardt, Britta [1 ]
机构：
[1] Univ Bern, Theodor Kocher Inst, CH-3012 Bern, Switzerland
来源：
JOURNAL OF CELL BIOLOGY | 2015年 / 209卷 / 04期
基金：
瑞士国家科学基金会;
关键词：
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CHOROID-PLEXUS EPITHELIUM; BLOOD-BRAIN; VE-CADHERIN; ENDOTHELIAL-CELLS; ADHESION MOLECULE; DIFFERENTIAL EXPRESSION; MULTIPLE-SCLEROSIS; BETA-CATENIN; IMMUNOGLOBULIN SUPERFAMILY;
D O I：
10.1083/jcb.201412147
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Unique intercellular junctional complexes between the central nervous system (CNS) microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial blood brain barrier (BBB) and the epithelial blood cerebrospinal fluid barrier (BCSFB), respectively. These barriers inhibit paracellular diffusion, thereby protecting the CNS from fluctuations in the blood. Studies of brain barrier integrity during development, normal physiology, and disease have focused on BBB and BCSFB tight junctions but not the corresponding endothelial and epithelial adherens junctions. The crosstalk between adherens junctions and tight junctions in maintaining barrier integrity is an understudied area that may represent a promising target for influencing brain barrier function.
引用
收藏
页码：493 / 506
页数：14
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