Tight Junctions of the Blood–Brain Barrier

被引：29
|
作者：
Uwe Kniesel
Hartwig Wolburg
机构：
[1] University of Tübingen,Institute of Pathology
来源：
Cellular and Molecular Neurobiology | 2000年 / 20卷
关键词：
tight junction; blood–brain barrier; morphology; freeze–fracture; cadherins; catenins; occludin; cytoskeleton;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
1. The blood–brain barrier is essential for the maintainance and regulation of the neural microenvironment. The blood–brain barrier endothelial cells comprise an extremely low rate of transcytotic vesicles and a restrictive paracellular diffusion barrier. The latter is realized by the tight junctions between the endothelial cells of the brain microvasculature, which are subject of this review. Morphologically, blood–brain barrier-tight junctions are more similar to epithelial tight junctions than to endothelial tight junctions in peripheral blood vessels.
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页码：57 / 76
页数：19
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