Antitumour activity of protein A in a mouse skin model of two-stage carcinogenesis

被引:11
|
作者
Shukla, Y
Verma, AS
Mehrotra, NK
Ray, PK
机构
[1] Indust. Toxicology Research Centre, M.G. Marg, Lucknow-226 001
[2] Department of Pharmacology, Tulana University Medical Centre, New Orleans, LA
[3] J.C. Bose Institute, Calcutta 700 009, 93/1, Acharya Prafful Chandra Road
关键词
protein A; antitumour activity; skin; mouse;
D O I
10.1016/0304-3835(96)04188-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Protein A (PA) is an immunostimulating glycoprotein (mel. wt. 43 000 kDa) obtained from Staphylococcus aureus cowan I. The antitumour property of PA is well documented in the literature in various transplantable rumours of rats and mice. In the present set of investigations, the antitumour property of PA was tested in Swiss albino mice in a two-stage initiation-promotion mouse skin carcinogenesis model. The animals were initiated topically with a single subcarcinogenic dose (52 mu g) of 7,12-dimethylbenzanthracene (DMBA). PA was administered intraperitoneally (1 mu g/animal), twice weekly for 2 weeks. Promotion was performed by twice weekly applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) at a dose of 5 mu g/animal for 32 weeks. The result showed that the treatment schedule can effectively check the onset of tumorigenesis, the cumulative number of tumours and the average number of tumours per mouse. In the PA administered group, 30% of the animals remained tumour free until the termination of the experiments (i.e. 32 weeks of promotion). Thus the present study proves that protein A can effectively inhibit DMBA initiated and TPA promoted mouse skin carcinogenesis.
引用
收藏
页码:41 / 47
页数:7
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