Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin

被引：0
|
作者：
Yasukawa, K
Akihisa, T
Kimura, Y
Tamura, T
Takido, M
机构：
[1] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan
[2] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, Tokyo 1018308, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1998年 / 21卷 / 10期
关键词：
rice bran; cycloartenol ferulate; anti-swelling; antitumor promoter; two-stage carcinogenesis;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice was observed in the methanol extract of rice bran and gamma-oryzanol. The active components of rice bran, sitosterol ferulate, 24-methylcholesterol ferulate, cycloartenol ferulate and 24-methylenecycloartanol ferulate inhibited markedly the TPA-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 0.2-0.3 mg/ear, Furthermore, cycloartenol ferulate markedly inhibited the tumor-promoting effect of TPA in 7,12-dimethylbenz[a] anthracene-initiated mice.
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页码：1072 / 1076
页数：5
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