Inhibitory Effects of Gymnema (Gymnema sylvestre) Leaves on Tumour Promotion in Two-Stage Mouse Skin Carcinogenesis

被引：3
|
作者：
Yasukawa, Ken [1 ]
Okuda, Sakiko [1 ]
Nobushi, Yasuhito [1 ]
机构：
[1] Nihon Univ, Sch Pharm, Funabashi, Chiba 2748555, Japan
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2014年 / 2014卷
关键词：
ANTISWEET NATURAL-PRODUCTS; R; BR; TRITERPENOID SAPONINS; MEDICINAL FOODSTUFFS; ACID; CONSTITUENTS; GYMNEMOSIDES; GLYCOSIDES; RATS; MICE;
D O I：
10.1155/2014/328684
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Ethanol extracts of gymnema (Gymnema sylvestre) leaves exhibited marked antitumour-promoting activity in an in vivo two-stage carcinogenesis test in mice using 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. From the active fraction of the ethanol extract of the gymnema leaves, three triterpenoids were isolated and identified. These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 mu g/ear) in mice. The tested compounds showed marked anti-inflammatory effects, with a 50% inhibitory dose of 50-555 nmol/ear.
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页数：5
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