HTRA proteases: regulated proteolysis in protein quality control

被引：368

作者：

Clausen, Tim ^{[1
]}

Kaiser, Markus ^{[2
]}

Huber, Robert ^{[2
,3
,4
]}

Ehrmann, Michael ^{[2
,4
]}

机构：

[1] Res Inst Mol Pathol IMP, A-1030 Vienna, Austria

[2] Univ Duisburg Essen, Ctr Med Biotechnol, Fac Biol, D-45117 Essen, Germany

[3] Max Planck Inst Biochem, D-82152 Martinsried, Germany

[4] Cardiff Univ, Sch Biosci, Cardiff CF10 3US, S Glam, Wales

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 03期

关键词：

HIGH-TEMPERATURE REQUIREMENT; AMYLOID PRECURSOR PROTEIN; IGF-BINDING PROTEINS; ENVELOPE-STRESS-RESPONSE; GROWTH-FACTOR IGF; SERINE-PROTEASE; ESCHERICHIA-COLI; PHOTOSYSTEM-II; PDZ DOMAIN; CRYSTAL-STRUCTURE;

D O I：

10.1038/nrm3065

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Controlled proteolysis underlies a vast diversity of protective and regulatory processes that are of key importance to cell fate. The unique molecular architecture of the widely conserved high temperature requirement A (HTRA) proteases has evolved to mediate critical aspects of ATP-independent protein quality control. The simple combination of a classic Ser protease domain and a carboxy-terminal peptide-binding domain produces cellular factors of remarkable structural and functional plasticity that allow cells to rapidly respond to the presence of misfolded or mislocalized polypeptides.

引用

下载

页码：152 / 162

页数：11

共 50 条

[21] Proteolysis of Surfactant Protein D by Cystic Fibrosis Relevant Proteases
C. von Bredow
A. Wiesener
M. Griese
Lung, 2003, 181 : 79 - 88
[22] Regulated Proteolysis as a Force to Control the Cell Cycle
Camberg, Jodi L.
Wickner, Sue
STRUCTURE, 2012, 20 (07) : 1128 - 1130
[23] The family of Deg/HtrA proteases in plants
Schuhmann, Holger
Huesgen, Pitter F.
Adamska, Iwona
BMC PLANT BIOLOGY, 2012, 12
[24] Insights into the Cyanobacterial Deg/HtrA Proteases
Cheregi, Otilia
Wagner, Raik
Funk, Christiane
FRONTIERS IN PLANT SCIENCE, 2016, 7
[25] The Repeating, Modular Architecture of the HtrA Proteases
Merski, Matthew
Macedo-Ribeiro, Sandra
Wieczorek, Rafal M.
Gorna, Maria W.
BIOMOLECULES, 2022, 12 (06)
[26] Proteolysis and autolysis of proteases and the detection of degradation products in doping control
Thomas, Andreas
Kohler, Maxie
Walpurgis, Katja
Schaenzer, Wilhelm
Thevis, Mario
DRUG TESTING AND ANALYSIS, 2009, 1 (1-2) : 81 - 86
[27] PROTEASES AND BIOLOGICAL-CONTROL BY LIMITED PROTEOLYSIS .1.
KORN, G
BERLINER UND MUNCHENER TIERARZTLICHE WOCHENSCHRIFT, 1978, 91 (15): : 304 - 309
[28] The family of Deg/HtrA proteases in plants
Holger Schuhmann
Pitter F Huesgen
Iwona Adamska
BMC Plant Biology, 12
[29] A protein quality control pathway regulated by linear ubiquitination
van Well, Eva M.
Bader, Verian
Patra, Maria
Sanchez-Vicente, Ana
Meschede, Jens
Furthmann, Nikolas
Schnack, Cathrin
Blusch, Alina
Longworth, Joseph
Petrasch-Parwez, Elisabeth
Mori, Kohji
Arzberger, Thomas
Truembach, Dietrich
Angersbach, Lena
Showkat, Cathrin
Sehr, Dominik A.
Berlemann, Lena A.
Goldmann, Petra
Clement, Albrecht M.
Behl, Christian
Woerner, Andreas C.
Saft, Carsten
Wurst, Wolfgang
Haass, Christian
Ellrichmann, Gisa
Gold, Ralf
Dittmar, Gunnar
Hipp, Mark S.
Hartl, F. Ulrich
Tatzelt, Joerg
Winklhofer, Konstanze F.
EMBO JOURNAL, 2019, 38 (09):
[30] Site-1 and site-2 proteases: A team of two in regulated proteolysis
Danyukova, Tatyana
Schoeneck, Kenneth
Pohl, Sandra
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2022, 1869 (01):

← 1 2 3 4 5 →