HTRA proteases: regulated proteolysis in protein quality control

被引：368

作者：

Clausen, Tim ^{[1
]}

Kaiser, Markus ^{[2
]}

Huber, Robert ^{[2
,3
,4
]}

Ehrmann, Michael ^{[2
,4
]}

机构：

[1] Res Inst Mol Pathol IMP, A-1030 Vienna, Austria

[2] Univ Duisburg Essen, Ctr Med Biotechnol, Fac Biol, D-45117 Essen, Germany

[3] Max Planck Inst Biochem, D-82152 Martinsried, Germany

[4] Cardiff Univ, Sch Biosci, Cardiff CF10 3US, S Glam, Wales

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 03期

关键词：

HIGH-TEMPERATURE REQUIREMENT; AMYLOID PRECURSOR PROTEIN; IGF-BINDING PROTEINS; ENVELOPE-STRESS-RESPONSE; GROWTH-FACTOR IGF; SERINE-PROTEASE; ESCHERICHIA-COLI; PHOTOSYSTEM-II; PDZ DOMAIN; CRYSTAL-STRUCTURE;

D O I：

10.1038/nrm3065

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Controlled proteolysis underlies a vast diversity of protective and regulatory processes that are of key importance to cell fate. The unique molecular architecture of the widely conserved high temperature requirement A (HTRA) proteases has evolved to mediate critical aspects of ATP-independent protein quality control. The simple combination of a classic Ser protease domain and a carboxy-terminal peptide-binding domain produces cellular factors of remarkable structural and functional plasticity that allow cells to rapidly respond to the presence of misfolded or mislocalized polypeptides.

引用

下载

页码：152 / 162

页数：11

共 50 条

[1] HTRA proteases: regulated proteolysis in protein quality control
Tim Clausen
Markus Kaiser
Robert Huber
Michael Ehrmann
Nature Reviews Molecular Cell Biology, 2011, 12 : 152 - 162
[2] Protein quality control and regulated proteolysis in the genome-reduced organism Mycoplasma pneumoniae
Burgos, Raul
Weber, Marc
Martinez, Sira
Lluch-Senar, Maria
Serrano, Luis
MOLECULAR SYSTEMS BIOLOGY, 2020, 16 (12)
[3] Deg/HtrA proteases as components of a network for photosystem II quality control in chloroplasts and cyanobacteria
Huesgen, Pitter F.
Schuhmann, Holger
Adamska, Iwona
RESEARCH IN MICROBIOLOGY, 2009, 160 (09) : 726 - 732
[4] Protein quality control: Triage by chaperones and proteases
Gottesman, S
Wickner, S
Maurizi, MR
GENES & DEVELOPMENT, 1997, 11 (07) : 815 - 823
[5] Protein quality control and membrane proteases in chloroplasts
Sakamoto, W
SEIKAGAKU, 2005, 77 (04): : 335 - 339
[6] PROTEASES AND BIOLOGICAL-CONTROL BY LIMITED PROTEOLYSIS
KORN, G
BERLINER UND MUNCHENER TIERARZTLICHE WOCHENSCHRIFT, 1978, 91 (16): : 313 - 318
[7] The HtrA family of proteases: Implications for protein composition and cell fate
Clausen, T
Southan, C
Ehrmann, M
MOLECULAR CELL, 2002, 10 (03) : 443 - 455
[8] Proteolysis in prokaryotes: protein quality control and regulatory principles
Hengge, R
Bukau, B
MOLECULAR MICROBIOLOGY, 2003, 49 (06) : 1451 - 1462
[9] Mitochondrial proteases and protein quality control in ageing and longevity
Hamon, Marie-Paule
Bulteau, Anne-Laure
Friguet, Bertrand
AGEING RESEARCH REVIEWS, 2015, 23 : 56 - 66
[10] Intramembrane Proteolysis in Regulated Protein Trafficking
Lemberg, Marius K.
TRAFFIC, 2011, 12 (09) : 1109 - 1118

← 1 2 3 4 5 →