Resistance Status and Evolution Trends of Klebsiella pneumoniae Isolates in a University Hospital in Greece: Ineffectiveness of Carbapenems and Increasing Resistance to Colistin

被引：34
|
作者：
Neonakis, I. K. [1 ]
Samonis, G. [2 ]
Messaritakis, H. [1 ]
Baritaki, S. [3 ]
Georgiladakis, A. [1 ]
Maraki, S. [1 ]
Spandidos, D. A. [1 ]
机构：
[1] Univ Hosp Herakl, Dept Clin Bacteriol Parasitol Zoonoses & Geog Med, GR-71201 Iraklion, Greece
[2] Univ Hosp Herakl, Dept Internal Med, GR-71201 Iraklion, Greece
[3] Univ Crete, Sch Med, Dept Lab Med, Iraklion, Greece
来源：
CHEMOTHERAPY | 2010年 / 56卷 / 06期
关键词：
Resistance patterns; Klebsiella pneumoniae; Colistin; Carbapenems; IN-VITRO ACTIVITY; NEGATIVE BACTERIA; TIGECYCLINE;
D O I：
10.1159/000320943
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Due to its increased non-susceptibility rates, Klebsiella pneumoniae has emerged as one of the most problematic pathogens. Methods: The level of resistance to 25 antimicrobials of K. pneumoniae isolates from a teaching hospital in Greece and the evolution trends during 2 decades were examined. Results: A statistically significant increase in non-susceptibility rates was found for almost all antimicrobials examined. During 2008, the isolates presented non-susceptibility rates to aminoglycosides >50% and to quinolones >60%. Nowadays, 1 out of 10 isolates is non-susceptible to colistin. Moreover, the isolates non-susceptible to imipenem were almost doubled between 2007 (29%) and 2008 (50%). Among the imipenem-resistant isolates, 1 out of 4 was also resistant to colistin. Conclusion: The effectiveness of carbapenems has been compromised and the increase in resistance to colistin is rapid and steep. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码：448 / 452
页数：5
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