IncP Plasmid Carrying Colistin Resistance Gene mcr-1 in Klebsiella pneumoniae from Hospital Sewage

被引：68
|
作者：
Zhao, Feifei [1 ,2 ]
Feng, Yu [1 ,2 ]
Lu, Xiaoju [1 ,2 ]
McNally, Alan [4 ]
Zong, Zhiyong [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, West China Hosp, Ctr Infect Dis, Chengdu, Peoples R China
[2] State Key Lab Biotherapy, Div Infect Dis, Chengdu, Peoples R China
[3] Sichuan Univ, Dept Infect Control, West China Hosp, Chengdu, Peoples R China
[4] Univ Birmingham, Inst Microbiol & Infect, Coll Med & Dent Sci, Birmingham, W Midlands, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 02期
基金：
中国国家自然科学基金;
关键词：
colistin resistance; mcr-1; sewage; Klebsiella pneumoniae; SPECTRUM-BETA-LACTAMASE; ESCHERICHIA-COLI; ENTEROBACTERIACEAE; DISSEMINATION; CARBAPENEM; ELEMENT; STRAIN;
D O I：
10.1128/AAC.02229-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A Klebsiella pneumoniae strain of sequence type 313 (ST313) recovered from hospital sewage was found carrying the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP-type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to spread beyond the Enterobacteriaceae family.
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页数：6
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