Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19

被引：57

作者：

Focosi, Daniele ^{[1
]}

Novazzi, Federica ^{[2
]}

Genoni, Angelo ^{[3
]}

Dentali, Francesco ^{[2
,3
]}

Gasperina, Daniela Dalla ^{[2
,3
]}

Baj, Andreina ^{[2
,3
]}

Maggi, Fabrizio ^{[2
,3
]}

机构：

[1] Pisa Univ Hosp, Pisa, Italy

[2] Azienda Sociosanitaria Terr, Varese, Italy

[3] Univ Insubria, Via Dunant 5, I-21100 Varese, Italy

来源：

EMERGING INFECTIOUS DISEASES | 2021年 / 27卷 / 10期

关键词：

D O I：

10.3201/eid2710.211538

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report in vivo selection of a severe acute respiratory syndrome coronavirus 2 spike mutation (Q493R) conferring simultaneous resistance to bamlanivimab and etesivimab. This mutation was isolated from a patient who had coronavirus disease and was treated with these drugs.

引用

页码：2728 / 2731

页数：4

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