White Matter Correlates of Apathy in HIV-Positive Subjects: A Diffusion Tensor Imaging Study

被引：42

作者：

Hoare, Jacqueline ^{[4
]}

Fouche, Jean-Paul ^{[1
]}

Spottiswoode, Bruce ^{[2
,3
]}

Joska, John A. ^{[4
]}

Schoeman, Renata

Stein, Dan J. ^{[1
,4
]}

Carey, Paul D. ^{[1
]}

机构：

[1] Univ Stellenbosch, Dept Psychiat, MRC Res Unit Anxiety Disorders, ZA-7600 Stellenbosch, South Africa

[2] Univ Cape Town, MRC Med Imaging Unit, ZA-7925 Cape Town, South Africa

[3] Univ Stellenbosch, Dept Radiol Sci & Oncol, ZA-7600 Stellenbosch, South Africa

[4] Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7925 Cape Town, South Africa

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2010年 / 22卷 / 03期

关键词：

ACTIVE ANTIRETROVIRAL THERAPY; CONSENSUS COGNITIVE BATTERY; ALZHEIMERS-DISEASE; BRAIN; RELIABILITY; DEMENTIA; VALIDITY; ABNORMALITIES; DEPRESSION; CIRCUITS;

D O I：

10.1176/appi.neuropsych.22.3.313

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Apathy is commonly reported by patients infected with HIV. No previous work has assessed the relationship between white matter and apathy in HIV. The authors aimed to determine whether apathy in HIV reflects a direct effect of the virus on subcortical brain regions or a secondary neuropsychiatric symptom. Thirteen HIV + participants with apathy, 13 HIV + participants with no apathy, and 10 healthy comparison subjects were examined using diffusion tensor imaging in the region of the anterior cingulate and corpus callosum. Results of the study confirmed the hypothesis which anticipated changes associated with apathy in white matter tracts that relay through the medial prefrontal cortex. (The Journal of Neuropsychiatry and Clinical Neurosciences 2010; 22:313-320)

引用

页码：313 / 320

页数：8

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