A Skin-Contact-Actuated Micropump for Transdermal Drug Delivery

被引：23
|
作者：
Mousoulis, Charilaos [1 ]
Ochoa, Manuel [1 ]
Papageorgiou, Demetrios [2 ]
Ziaie, Babak [1 ]
机构：
[1] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47906 USA
[2] Solid State Res Inc, Natick, MA 01760 USA
来源：
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2011年 / 58卷 / 05期
基金：
美国国家科学基金会;
关键词：
Microfluidics; micropump; phase-change liquid; polydimethylsiloxane (PDMS); transdermal drug delivery; MICROFLUIDIC DEVICES; PDMS; DESIGN; MEMS; PERMEATION; VALVES; CHIP; PUMP;
D O I：
10.1109/TBME.2011.2113347
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this paper, a skin-contact-actuated dispenser/micropump for transdermal drug delivery applications is presented. The micropump consists of stacked polydimethylsiloxane layers mounted on a silicon substrate and operates based on the evaporation and condensation of a low-boiling-point liquid. Therefore, there is no need for a heater and a power source, since only the thermal energy provided by skin contact is required for the actuation. A prototype device with overall dimensions of 14 mm x 14 mm x 8 mm is fabricated and characterized. For a perfluoro compound working fluid (3M FC-3284), a flow rate of 28.8 mu L/min and a maximum back pressure of 28.9 kPa is measured.
引用
收藏
页码：1492 / 1498
页数：7
相关论文
共 50 条
  • [1] Design of Transdermal Drug Delivery System with PZT actuated micropump
    Dolzan, T.
    Vrtacnik, D.
    Resnik, D.
    Aljancic, U.
    Mozek, M.
    Pecar, B.
    Amon, S.
    [J]. 2014 37TH INTERNATIONAL CONVENTION ON INFORMATION AND COMMUNICATION TECHNOLOGY, ELECTRONICS AND MICROELECTRONICS (MIPRO), 2014, : 96 - 99
  • [2] Experimentation of an electrostatically actuated monochip micropump for drug delivery
    Dilhan, M
    Tasselli, J
    Esteve, D
    Temple-Boyer, P
    Camon, H
    Anduze, M
    Colin, S
    [J]. DESIGN, TEST, AND MICROFABRICATION OF MEMS AND MOEMS, PTS 1 AND 2, 1999, 3680 : 887 - 896
  • [3] Design and simulation of a piezoelectrically actuated micropump for the drug delivery system
    Cui, Qifeng
    Liu, Chengliang
    Zha, Xuan F.
    [J]. 2006 IEEE INTERNATIONAL CONFERENCE ON AUTOMATION SCIENCE AND ENGINEERING, VOLS 1 AND 2, 2006, : 45 - +
  • [4] Skin electroporation for transdermal drug delivery
    Vanbever, R
    Weaver, JC
    Préat, V
    [J]. ELECTRICITY AND MAGNETISM IN BIOLOGY AND MEDICINE, 1999, : 907 - 910
  • [5] Transdermal Drug Delivery in the Pig Skin
    Ordiz, Ignacio
    Vega, Jose A.
    Martin-Sanz, Raquel
    Garcia-Suarez, Olivia
    del Valle, Miguel E.
    Feito, Jorge
    [J]. PHARMACEUTICS, 2021, 13 (12)
  • [6] MICRO CHECK VALVE INTEGRATED MAGNETICALLY ACTUATED MICROPUMP FOR IMPLANTABLE DRUG DELIVERY
    Wang, Cong
    Kim, Jin-seong
    Park, Jungyul
    [J]. 2017 19TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS), 2017, : 1711 - 1713
  • [7] An Electromagnetically-Actuated All-PDMS Valveless Micropump for Drug Delivery
    Zhou, Yu
    Amirouche, Farid
    [J]. MICROMACHINES, 2011, 2 (03): : 345 - 355
  • [8] THE SKIN COMPLIANCE OF TRANSDERMAL DRUG DELIVERY SYSTEMS
    BODDE, HE
    VERHOEVEN, J
    VANDRIEL, LMJ
    [J]. CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 1989, 6 (01): : 87 - 115
  • [9] Skin Impedance Models for Transdermal Drug Delivery
    Pang, Grantham K. H.
    Qiao, DaPeng
    [J]. 2009 IEEE INTERNATIONAL CONFERENCE ON MECHATRONICS AND AUTOMATION, VOLS 1-7, CONFERENCE PROCEEDINGS, 2009, : 1784 - 1788
  • [10] SKIN COMPATIBILITY OF TRANSDERMAL DRUG DELIVERY SYSTEMS
    KURIHARABERGSTROM, T
    GOOD, WR
    FEISULLIN, S
    SIGNOR, C
    [J]. JOURNAL OF CONTROLLED RELEASE, 1991, 15 (03) : 271 - 278
12345