SKIN COMPATIBILITY OF TRANSDERMAL DRUG DELIVERY SYSTEMS

被引：9
|
作者：
KURIHARABERGSTROM, T
GOOD, WR
FEISULLIN, S
SIGNOR, C
机构：
[1] CIBA-GEIGY Corporation, Pharmaceutics Division, Ardsley, NY
来源：
JOURNAL OF CONTROLLED RELEASE | 1991年 / 15卷 / 03期
关键词：
TRANSDERMAL; CONTACT ALLERGIC DERMATITIS; ARECOLINE; ALZHEIMERS DISEASE;
D O I：
10.1016/0168-3659(91)90119-X
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This article discusses factors affecting the results of contact allergic dermatitis (CAD) with respect to transdermal dosage form development, reviewing our experience in the development of TTS-are-coline for the treatment of Alzheimer's disease. A significant improvement in responses of CAD was demonstrated in a in vivo guinea pig model by altering physical chemical properties of the transdermal dosage forms. An immunologic response to a new transdermal candidate compound may selectively be manipulated to prevent CAD.
引用
收藏
页码：271 / 278
页数：8
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