Predicting enzyme class from protein structure using Bayesian classification

被引:0
|
作者
Borro, Luiz C. [1 ]
Oliveira, Stanley R. M. [1 ]
Yamagishi, Michel E. B. [1 ]
Mancini, Adaulto L. [1 ]
Jardine, Jose G. [1 ]
Mazoni, Ivan [1 ]
dos Santos, Edgard H. [1 ]
Higa, Roberto H. [1 ]
Kuser, Paula R. [1 ]
Neshich, Goran [1 ]
机构
[1] Embrapa Informat Technol, BR-13083886 Campinas, SP, Brazil
关键词
protein function prediction; protein structure; Naive Bayes; enzyme classification number; Bayesian classifier; data classification;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Predicting enzyme class from protein structure parameters is a challenging problem in protein analysis. We developed a method to predict enzyme class that combines the strengths of statistical and data-mining methods. This method has a strong mathematical foundation and is simple to implement, achieving an accuracy of 45%. A comparison with the methods found in the literature designed to predict enzyme class showed that our method outperforms the existing methods.
引用
收藏
页码:193 / 202
页数:10
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