Rhodium(III)-Catalyzed Oxidative Annulation of 4-Aminoquinolines and Acrylate through Two Consecutive C(sp2)-H Activations

被引：2

作者：

Liu, Jian ^{[1
]}

Gao, Yi ^{[1
]}

Zhu, Yehua ^{[1
]}

Zhu, Junru ^{[1
]}

Wang, Chao ^{[1
]}

Rui, Xiyan ^{[1
]}

Yang, Kundi ^{[2
]}

Si, Dongjuan ^{[1
]}

Lin, Jiamin ^{[1
]}

Yuan, Dandan ^{[1
]}

Wen, Hongmei ^{[1
]}

Li, Wei ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Peoples R China

[2] Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 07期

基金：

美国国家科学基金会;

关键词：

QUINOLINE N-OXIDES; H BOND FUNCTIONALIZATIONS; C-N; OLEFINATION; PALLADIUM; CHELATION; ALKYNES; PICOLINAMIDES; DERIVATIVES; ANTIFUNGAL;

D O I：

10.1021/acs.orglett.0c00630

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-H annulation of the five-position of quinolines and acrylates to afford heterocycles is an active field of research in organic synthesis. Herein the annulation of 4-aminoquinolines with acrylates through two consecutive C-H activations catalyzed by Rh(III) is described. The reaction proceeds with high atom efficiency under mild reaction conditions, and this protocol will provide appealing strategies for the synthesis of fused quinoline heterocycles.

引用

页码：2657 / 2662

页数：6

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