Rhodium-Catalyzed Oxidative ortho-Acylation of Benzamides with Aldehydes: Direct Functionalization of the sp2 C-H Bond

被引：146
|
作者：
Park, Jihye [1 ]
Park, Eonjeong [1 ]
Kim, Aejin [1 ]
Lee, Youngil [1 ]
Chi, Ki-Whan [1 ]
Kwak, Jong Hwan [2 ]
Jung, Young Hoon [2 ]
Kim, In Su [1 ]
机构：
[1] Univ Ulsan, Dept Chem, Ulsan 680749, South Korea
[2] Sungkyunkwan Univ, Sch Pharm, Suwon 440746, South Korea
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 16期
关键词：
DIRECT ARYLATION; ACTIVATION; ACETANILIDES; OLEFINATION; ALKYNES; COUPLING/CYCLIZATION; BENZOPHENONES; CONSTRUCTION; FLUORINATION; DERIVATIVES;
D O I：
10.1021/ol201729w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rhodium-catalyzed oxidative acylation of benzamides with aryl aldehydes via direct sp(2) C-H bond cleavage is described. In the presence of [Cp*RhCl2](2), AgSbF6, and silver carbonate as an oxidant, N,N-diethyl benzamides can be effectively carbonylated to yield ortho-acyl benzamides.
引用
收藏
页码：4390 / 4393
页数：4
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