Palladium-Catalyzed ortho-Acylation of Acetanilides with Aldehydes through Direct C-H Bond Activation

被引：135
|
作者：
Li, Chengliang [1 ]
Wang, Lei [1 ,2 ]
Li, Pinhua [1 ]
Zhou, Wei [1 ]
机构：
[1] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China
[2] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 37期
基金：
中国国家自然科学基金;
关键词：
acetanilides; aldehydes; C-H activation; palladium; synthetic methods; BENZOPHENONE RELATED-COMPOUNDS; ALPHA-OXOCARBOXYLIC ACIDS; CROSS-COUPLING REACTIONS; CARBON-HYDROGEN BONDS; ORTHO-ARYLATION; ROOM-TEMPERATURE; SIMPLE ARENES; ARYL HALIDES; FUNCTIONALIZATION; SP(2);
D O I：
10.1002/chem.201101192
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Easy access to o-acyl acetanilides: A new Pd-catalyzed ortho-acylation of acetanilides with both aromatic and aliphatic aldehydes has been developed based on a Ci-H activation process. In the presence of tert-butyl hydroperoxide (TBHP) as the ideal oxidant, this reaction provides an efficient access to ortho-acyl acetanilides in good yields (see scheme). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：10208 / 10212
页数：5
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