Complementary detection of prostate-specific antigen using ln2O3 nanowires and carbon nanotubes

被引：328

作者：

Li, C

Curreli, M

Lin, H

Lei, B

Ishikawa, FN

Datar, R

Cote, RJ

Thompson, ME

Zhou, CW ^{[1
]}

机构：

[1] Univ So Calif, Dept Elect Engn, Los Angeles, CA 90089 USA

[2] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA

[3] Univ So Calif, Dept Pathol, Los Angeles, CA 90089 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 36期

关键词：

D O I：

10.1021/ja053761g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer. Copyright © 2005 American Chemical Society.

引用

页码：12484 / 12485

页数：2

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