Complementary detection of prostate-specific antigen using ln2O3 nanowires and carbon nanotubes

被引：328
|
作者：
Li, C
Curreli, M
Lin, H
Lei, B
Ishikawa, FN
Datar, R
Cote, RJ
Thompson, ME
Zhou, CW [1 ]
机构：
[1] Univ So Calif, Dept Elect Engn, Los Angeles, CA 90089 USA
[2] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA
[3] Univ So Calif, Dept Pathol, Los Angeles, CA 90089 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 36期
关键词：
D O I：
10.1021/ja053761g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer. Copyright © 2005 American Chemical Society.
引用
收藏
页码：12484 / 12485
页数：2
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