Pancreatic beta cell-selective deletion of the mitofusins 1 and 2 9Mfn1 and Mfn2) strongly impairs glucose-stimulated insulin secretion in vivo

被引:0
|
作者
Georgiadou, E. [1 ]
Rodriguez, T. A. [2 ]
Rutter, G. A. [1 ]
机构
[1] Imperial Coll London, Dept Med, London, England
[2] Imperial Coll London, Imperial Ctr Translat & Expt Med, London, England
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A60
引用
收藏
页码:26 / 26
页数:1
相关论文
共 50 条
  • [31] Low-Level Inorganic Arsenite Impairs Glucose-Stimulated Insulin Secretion in Pancreatic Beta-Cells: Involvement of Nrf2-Mediated Antioxidant Response
    Fu, Jingqi
    Woods, Courtney G.
    Shnaidman, Einav
    Zhang, Qiang
    Andersen, Melvin E.
    Collins, Sheila
    Pi, Jingbo
    FREE RADICAL BIOLOGY AND MEDICINE, 2008, 45 : S156 - S157
  • [32] The role of interleukin-1β and extracellular signal-regulated kinase 1/2 in glucose-stimulated insulin secretion
    Niu, Ben
    Su, Heng
    Xia, Xue-Shan
    He, Qiu
    Xue, Yuan-Ming
    Yan, Xin-Ming
    KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2017, 33 (05): : 224 - 228
  • [33] Preserved insulin secretion despite impaired glucose signalling after pancreatic beta cell selective deletion of the tumour suppressor LKB1
    Sayers, S.
    Kantor, C.
    Pullen, T. J.
    Nguyen-Tu, M. S.
    Hodson, D. J.
    McGinty, J.
    Lingling, C.
    French, P.
    Ibberson, M.
    Thorens, B.
    DIABETIC MEDICINE, 2015, 32 : 13 - 13
  • [34] Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice
    Cantley, J.
    Choudhury, A. I.
    Asare-Anane, H.
    Selman, C.
    Lingard, S.
    Heffron, H.
    Herrera, P.
    Persaud, S. J.
    Withers, D. J.
    DIABETOLOGIA, 2007, 50 (06) : 1248 - 1256
  • [35] Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice
    J. Cantley
    A. I. Choudhury
    H. Asare-Anane
    C. Selman
    S. Lingard
    H. Heffron
    P. Herrera
    S. J. Persaud
    D. J. Withers
    Diabetologia, 2007, 50 : 1248 - 1256
  • [36] Perfluorooctane sulfonate continual exposure impairs glucose-stimulated insulin secretion via SIRT1-induced upregulation of UCP2 expression
    Duan, Xiaoyu
    Sun, Weijie
    Sun, Hongwen
    Zhang, Lianying
    ENVIRONMENTAL POLLUTION, 2021, 278
  • [37] Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets
    Desirée Edén
    Agneta Siegbahn
    Dariush Mokhtari
    Diabetologia, 2015, 58 : 2563 - 2572
  • [38] Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets
    Eden, Desiree
    Siegbahn, Agneta
    Mokhtari, Dariush
    DIABETOLOGIA, 2015, 58 (11) : 2563 - 2572
  • [39] The effect of endurance training with crocin consumption on the levels of MFN2 and DRP1 gene expression and glucose and insulin indices in the muscle tissue of diabetic rats
    Peyravi, Abdolnabi
    Yazdanpanahi, Nasrin
    Nayeri, Hashem
    Hosseini, Seyyed Ali
    JOURNAL OF FOOD BIOCHEMISTRY, 2020, 44 (02)
  • [40] Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes
    Z. Asghar
    D. Yau
    F. Chan
    D. LeRoith
    C. B. Chan
    M. B. Wheeler
    Diabetologia, 2006, 49 : 90 - 99