Preserved insulin secretion despite impaired glucose signalling after pancreatic beta cell selective deletion of the tumour suppressor LKB1

被引:0
|
作者
Sayers, S. [1 ]
Kantor, C. [1 ]
Pullen, T. J. [1 ]
Nguyen-Tu, M. S. [1 ]
Hodson, D. J. [1 ]
McGinty, J. [2 ]
Lingling, C. [2 ]
French, P. [2 ]
Ibberson, M. [3 ]
Thorens, B. [3 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Sect Cell Biol, Div Diabet Endocrinol & Metab, London, England
[2] Univ London Imperial Coll Sci Technol & Med, Sect Photon, Dept Phys, London, England
[3] Univ Lausanne, Ctr Integrat Genom, Lausanne, Switzerland
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A37 (P14)
引用
收藏
页码:13 / 13
页数:1
相关论文
共 38 条
  • [1] LKB1 is required for normal glucose-signalling, but not insulin secretion, in pancreatic beta cells
    Sayers, S.
    Hodson, D. J.
    Spegel, P.
    Mulder, H.
    Swisa, A.
    Dor, Y.
    Rutter, G. A.
    DIABETOLOGIA, 2015, 58 : S215 - S216
  • [2] LKB1 deletion with the RIP2.Cre transgene modifies pancreatic β-cell morphology and enhances insulin secretion in vivo
    Sun, Gao
    Tarasov, Andrei I.
    McGinty, James A.
    French, Paul M.
    McDonald, Angela
    Leclerc, Isabelle
    Rutter, Guy A.
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2010, 298 (06): : E1261 - E1273
  • [3] Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects
    Swisa, Avital
    Granot, Zvi
    Tamarina, Natalia
    Sayers, Sophie
    Bardeesy, Nabeel
    Philipson, Louis
    Hodson, David J.
    Wikstrom, Jakob D.
    Rutter, Guy A.
    Leibowitz, Gil
    Glaser, Benjamin
    Dor, Yuval
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (34) : 20934 - 20946
  • [4] Deletion of beta-arrestin-2 impaired glucose induced insulin secretion from pancreatic islet cells
    Wang, C.
    Zhang, M.
    Li, L.
    Zhu, Y.
    Zhao, J.
    Jia, W.
    DIABETOLOGIA, 2011, 54 : S259 - S260
  • [5] Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E
    Fiory, F.
    Lombardi, A.
    Miele, C.
    Giudicelli, J.
    Beguinot, F.
    Van Obberghen, E.
    DIABETOLOGIA, 2011, 54 (11) : 2941 - 2952
  • [6] Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E
    F. Fiory
    A. Lombardi
    C. Miele
    J. Giudicelli
    F. Beguinot
    E. Van Obberghen
    Diabetologia, 2011, 54 : 2941 - 2952
  • [7] Deletion of beta cell specific KATP channels causes severe glucose intolerance with impaired insulin secretion and enhanced incretin secretion
    Oduori, O. S.
    Minami, K.
    Yokoi, N.
    Maejima, Y.
    Takahashi, H.
    Herrera, P. L.
    Shimomura, K.
    Seino, S.
    DIABETOLOGIA, 2016, 59 : S85 - S85
  • [8] Pancreatic beta cell-selective deletion of the mitochondrial calcium uniporter (MCU) impairs glucose-stimulated insulin secretion in vitro but not in vivo
    Rutter, G. A.
    Haythorne, E. A.
    Georgiadou, E.
    Xavier, G. da Silva
    Pullen, T. J.
    Rizzuto, R.
    Martinez-Sanchez, A.
    McGinty, J. A.
    French, P. M.
    DIABETIC MEDICINE, 2018, 35 : 42 - 42
  • [9] Erratum to: Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E
    F. Fiory
    A. Lombardi
    C. Miele
    J. Giudicelli
    F. Beguinot
    E. Van Obberghen
    Diabetologia, 2012, 55 : 272 - 272
  • [10] Pancreatic beta cell-selective deletion of themitofusins 1 and 2 (Mfn1 and Mfn2) impairs glucose-stimulated insulin secretion in vitro and in vivo
    Rutter, G. A.
    Georgiadou, E.
    Rodriguez, T.
    Muralidharan, C.
    Martinez, M.
    Chabosseau, P.
    Tomas, A.
    Carrat, G.
    Di Gregorio, A.
    Leclerc, I.
    Linnemann, A. K.
    DIABETOLOGIA, 2020, 63 (SUPPL 1) : S6 - S7