11H-Indeno[1,2-b]quinoxalin-11-one 2-(4-ethylbenzylidene)hydrazone

被引：5

作者：

Kovrizhina, Anastasia R. ^{[1
]}

Samorodova, Elizaveta I. ^{[1
]}

Khlebnikov, Andrei I. ^{[1
,2
]}

机构：

[1] Tomsk Polytech Univ, Kizhner Res Ctr, Tomsk 634050, Russia

[2] Altai State Univ, Sci Res Inst Biol Med, Barnaul 656049, Russia

来源：

MOLBANK | 2021年 / 2021卷 / 04期

基金：

俄罗斯科学基金会;

关键词：

azine; aldazine; 11H-indeno[1; 2-b]quinoxalin-11-one; DFT; ADME; DERIVATIVES; BOND; GUANYLHYDRAZONES; HYDRAZONES; FACILE; AZINE;

D O I：

10.3390/M1299

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

11H-Indeno[1,2-b]quinoxaline derivatives present an important type of nitrogen-containing heterocyclic compound that are useful intermediate products in organic synthesis and have potential pharmaceutical applications. A new 11H-indeno[1,2-b]quinoxalin-11-one-2-(4-ethylbenzylidene)hydrazone (compound 3) was synthesized. Compound 3 is the first example of an azine derivative based on the 11H-indeno[1,2-b]quinoxaline system. The Z,E-isomerism of compound 3 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME predictions. According to the ADME results, compound 3 is potentially highly bioavailable and has potential to be used for the treatment of neuroinflammation and ischemia-reperfusion injury.

引用

页数：7

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