11H-Indeno[1,2-b]quinoxalin-11-one 2-(4-ethylbenzylidene)hydrazone

被引：5
|
作者：
Kovrizhina, Anastasia R. [1 ]
Samorodova, Elizaveta I. [1 ]
Khlebnikov, Andrei I. [1 ,2 ]
机构：
[1] Tomsk Polytech Univ, Kizhner Res Ctr, Tomsk 634050, Russia
[2] Altai State Univ, Sci Res Inst Biol Med, Barnaul 656049, Russia
来源：
MOLBANK | 2021年 / 2021卷 / 04期
基金：
俄罗斯科学基金会;
关键词：
azine; aldazine; 11H-indeno[1; 2-b]quinoxalin-11-one; DFT; ADME; DERIVATIVES; BOND; GUANYLHYDRAZONES; HYDRAZONES; FACILE; AZINE;
D O I：
10.3390/M1299
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
11H-Indeno[1,2-b]quinoxaline derivatives present an important type of nitrogen-containing heterocyclic compound that are useful intermediate products in organic synthesis and have potential pharmaceutical applications. A new 11H-indeno[1,2-b]quinoxalin-11-one-2-(4-ethylbenzylidene)hydrazone (compound 3) was synthesized. Compound 3 is the first example of an azine derivative based on the 11H-indeno[1,2-b]quinoxaline system. The Z,E-isomerism of compound 3 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME predictions. According to the ADME results, compound 3 is potentially highly bioavailable and has potential to be used for the treatment of neuroinflammation and ischemia-reperfusion injury.
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页数：7
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