Synthesis and antileishmanial and antimicrobial activities of some 2,3-disubstituted 3H-quinazolin-4-ones

被引：17
|
作者：
Arfan, Muhammad [1 ]
Khan, Rasool [2 ]
Khan, Murad Ali [3 ]
Anjum, Shazia [4 ]
Choudhary, Muhammad Iqbal [5 ]
Ahmad, Manzoor [6 ]
机构：
[1] Univ Peshawar, Inst Chem Sci, Peshawar 25120, Pakistan
[2] Abdul Wali Khan Univ, Dept Chem, Mardan, Pakistan
[3] PCSIR Labs Complex Peshawar NWFP, Peshawar, Pakistan
[4] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 0W0, Canada
[5] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 32, Pakistan
[6] Univ Malakand, Dept Chem, Chakdara, Pakistan
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2010年 / 25卷 / 04期
关键词：
2,3-disubstituted quinazolin-4(3H)-ones; synthesis; antileishmanial activities; antimicrobial activities; ONE-POT SYNTHESIS;
D O I：
10.3109/14756360903309412
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of 2,3-disubstituted 3H-quinazolin-4-ones was synthesized. Antimicrobial activities of the synthesized compounds were investigated against Gram (+ve) and Gram (-ve) bacteria, including B. subtilis, S. aureus, S. flexneri, P. aeruginosa, and S. typhi, and six fungi, namely Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, and Candida glabrata using the broth microdilution method. Compounds 9, 11, and 12 showed significant activities against the selected bacterial cultures, while 7-10, 12, 15, and 16 showed good to moderate antifungal activities. Compound 11 exhibited strongest leishmanicidal activity against Leishmania major (MHOM/PK/88/DESTO) promastigotes, while other compounds showed weak to moderate leishmanicidal activities.
引用
收藏
页码：451 / 458
页数：8
相关论文
共 50 条
  • [41] REGIOSPECIFIC SYNTHESIS OF 1,3-DISUBSTITUTED AND 2,3-DISUBSTITUTED INDENO[1,2-C]PYRAZOL-4H-ONES
    SAWHNEY, KN
    LEMKE, TL
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1982, 184 (SEP): : 114 - ORGN
  • [42] Synthesis, characterization and in vitro antimicrobial studies of new 2,3-disubstituted quinazolin-4(3H) ones of 2-[2-(2,6-dichlorophenyl)amino]phenyl acetic acid
    Patel, Navin B.
    Shaikh, Asif R.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2010, 49 (07): : 929 - 936
  • [43] Substituted 2-(2-hydroxyphenyl)-3H-quinazolin-4-ones and their difluoroboron complexes: Synthesis and photophysical properties
    Moshkina, Tatyana N.
    Nosova, Emiliya, V
    Lipunova, Galina N.
    Valova, Marina S.
    Petrusevich, Elizaveta F.
    Zalesny, Robert
    Osmialowski, Borys
    Charushin, Valery N.
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2021, 252
  • [44] Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists
    Storelli, Stefania
    Verzijl, Dennis
    Al-Badie, Jawad
    Elders, Niels
    Bosch, Leontien
    Timmerman, Henk
    Smit, Martine J.
    De Esch, Iwan J. P.
    Leurs, Rob
    ARCHIV DER PHARMAZIE, 2007, 340 (06) : 281 - 291
  • [45] Synthesis of a Novel Series of 2,3-Disubstituted Quinazolin-4(3H)-ones as a Product of a Nucleophilic Attack at C(2) of the Corresponding 4H-3,1-Benzoxazin-4-one
    El-Hashash, Mahr A.
    El-Badry, Yaser A.
    HELVETICA CHIMICA ACTA, 2011, 94 (03) : 389 - 396
  • [46] Radical reactions with 3H-quinazolin-4-ones:: synthesis of deoxyvasicinone, mackinazolinone, luotonin A, rutaecarpine and tryptanthrin
    Bowman, W. Russell
    Elsegood, Mark R. J.
    Stein, Tobias
    Weaver, George W.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (01) : 103 - 113
  • [47] Synthesis and fungicidal activities of 2-alkoxy-3H-quinazolin-4-ones
    Ding, MW
    Yang, SJ
    Chen, YF
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2004, 24 (08) : 923 - 926
  • [48] Synthesis of 2, 3-disubstituted quinazolone derivatives for analgesic and antimicrobial activities
    Thirugnanasambanthan, A.
    Sankarnarayanan, S.
    Journal of Chemical and Pharmaceutical Research, 2012, 4 (02) : 1147 - 1150
  • [49] Catalytic activity of TiO2 nanoparticles in the synthesis of some 2,3-disubstituted dihydroquinazolin-4(1H)-ones
    Bharathi, A.
    Roopan, Selvaraj Mohana
    Kajbafvala, Amir
    Padmaja, R. D.
    Darsana, M. S.
    Kumari, G. Nandhini
    CHINESE CHEMICAL LETTERS, 2014, 25 (02) : 324 - 326
  • [50] Facile Synthesis and Herbicidal Evaluation of 4H-3,1-Benzoxazin-4-ones and 3H-Quinazolin-4-ones with 2-Phenoxymethyl Substituents
    Aibibuli, Zumuretiguli
    Wang, Yufeng
    Tu, Haiyang
    Huang, Xiaoting
    Zhang, Aidong
    MOLECULES, 2012, 17 (03) : 3181 - 3201
12345