Synthesis and antileishmanial and antimicrobial activities of some 2,3-disubstituted 3H-quinazolin-4-ones

被引：17
|
作者：
Arfan, Muhammad [1 ]
Khan, Rasool [2 ]
Khan, Murad Ali [3 ]
Anjum, Shazia [4 ]
Choudhary, Muhammad Iqbal [5 ]
Ahmad, Manzoor [6 ]
机构：
[1] Univ Peshawar, Inst Chem Sci, Peshawar 25120, Pakistan
[2] Abdul Wali Khan Univ, Dept Chem, Mardan, Pakistan
[3] PCSIR Labs Complex Peshawar NWFP, Peshawar, Pakistan
[4] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 0W0, Canada
[5] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 32, Pakistan
[6] Univ Malakand, Dept Chem, Chakdara, Pakistan
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2010年 / 25卷 / 04期
关键词：
2,3-disubstituted quinazolin-4(3H)-ones; synthesis; antileishmanial activities; antimicrobial activities; ONE-POT SYNTHESIS;
D O I：
10.3109/14756360903309412
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of 2,3-disubstituted 3H-quinazolin-4-ones was synthesized. Antimicrobial activities of the synthesized compounds were investigated against Gram (+ve) and Gram (-ve) bacteria, including B. subtilis, S. aureus, S. flexneri, P. aeruginosa, and S. typhi, and six fungi, namely Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, and Candida glabrata using the broth microdilution method. Compounds 9, 11, and 12 showed significant activities against the selected bacterial cultures, while 7-10, 12, 15, and 16 showed good to moderate antifungal activities. Compound 11 exhibited strongest leishmanicidal activity against Leishmania major (MHOM/PK/88/DESTO) promastigotes, while other compounds showed weak to moderate leishmanicidal activities.
引用
收藏
页码：451 / 458
页数：8
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