Cryptococcal glucuronoxylomannan delays translocation of leukocytes across the blood-brain barrier in an animal model of acute bacterial meningitis

被引：25

作者：

Lipovsky, MM

Tsenova, L

Coenjaerts, FEJ

Kaplan, G

Cherniak, R

Hoepelman, AIM

机构：

[1] Univ Utrecht, Med Ctr, Eijkman Winkler Inst, Div Infect Dis & AIDS,Dept Med, NL-3508 GA Utrecht, Netherlands

[2] Rockefeller Univ, Cellular Physiol & Immunol Lab, New York, NY 10021 USA

[3] Georgia State Univ, Dept Chem, Lab Biol & Chem Sci, Atlanta, GA 30303 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 111卷 / 1-2期

关键词：

bacterial meningitis; leukocytes; GXM; inflammation;

D O I：

10.1016/S0165-5728(00)00354-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In bacterial meningitis, neurological damage is associated with a high influx of polymorphonuclear leukocytes (PMN) into the brain. Previous data suggest that the capsular component of the fungus C. neoformans, glucuronoxylomannan (GXM), interferes with PMN-migration into the cerebrospinal fluid (CSF). Therefore, a rabbit model of bacterial meningitis was treated intravenously with GXM. This resulted in (1) a reduction of PMN in the CSF at 6 h (P=0.05), (2) reduced peak TNF-alpha concentrations in the CSF, and (3) diminished tissue inflammation and intravascular margination of PMN in GXM-treated animals. Thus, GXM may represent a novel adjuvant anti-inflammatory agent in bacterial meningitis. (C) 2000 Published by Elsevier Science B.V.

引用

页码：10 / 14

页数：5

共 50 条

[31] An insight into the ligand-receptor interactions involved in the translocation of pathogens across blood-brain barrier
Bencurova, Elena
Mlynarcik, Patrik
Bhide, Mangesh
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2011, 63 (03): : 297 - 318
[32] Ultrathin Silicon Membranes for in Situ Optical Analysis of Nano article Translocation across an a Human Blood-Brain Barrier Model
Hudecz, Diana
Khire, Tejas
Chung, Hung Li
Adumeau, Laurent
Glavin, Dale
Luke, Emma
Nielsen, Morten S.
Dawson, Kenneth A.
McGrath, James L.
Yan, Yan
ACS NANO, 2020, 14 (01) : 1111 - 1122
[33] Inhibition of Leptin-ObR Interaction Does not Prevent Leptin Translocation Across a Human Blood-Brain Barrier Model
Gonzalez-Carter, D.
Goode, A. E.
Fiammengo, R.
Dunlop, I. E.
Dexter, D. T.
Porter, A. E.
JOURNAL OF NEUROENDOCRINOLOGY, 2016, 28 (06)
[34] Of cytokine receptor scissors, grasping bacterial hands, and movement across the blood-brain barrier
Adler, Elizabeth M.
JOURNAL OF GENERAL PHYSIOLOGY, 2014, 144 (01): : 4 - 5
[35] Role of blood-brain barrier in an animal model of cortical progressive multiple sclerosis
Silva, B. A.
Leal, M. C.
Farias, M. I.
Pitossi, F. J.
Ferrari, C. C.
MULTIPLE SCLEROSIS JOURNAL, 2016, 22 : 166 - 166
[36] Pertussis toxin enhances the translocation of pathogenic bacteria in a human blood-brain barrier model
Boecker, K.
Schulte, J.
Wewer, C.
Greune, L.
Humberg, V.
Kim, K. -S.
Schmidt, M. A.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2007, 297 : 136 - 136
[37] Transcellular Model for Neutral and Charged Nanoparticles Across an In Vitro Blood-Brain Barrier
Zhang, Lin
Fan, Jie
Li, Guanglei
Yin, Zhaokai
Fu, Bingmei M.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY, 2020, 11 (06) : 607 - 620
[38] Transport of treosulfan and temozolomide across an in-vitro blood-brain barrier model
Linz, Ute
Hupert, Michelle
Santiago-Schuebel, Beatrix
Wien, Sascha
Stab, Julia
Wagner, Sylvia
ANTI-CANCER DRUGS, 2015, 26 (07) : 728 - 736
[39] Peptide-Based Delivery of Oligonucleotides Across Blood-Brain Barrier Model
Srimanee, Artita
Regberg, Jakob
Hallbrink, Mattias
Kurrikoff, Kaido
Veiman, Kadi-Liis
Vajragupta, Opa
Langel, Ulo
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2014, 20 (02) : 169 - 178
[40] A mathematical model for prediction of drug molecule diffusion across the blood-brain barrier
Burns, J
Weaver, DF
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2004, 31 (04) : 520 - 527

← 1 2 3 4 5 →