Cryptococcal glucuronoxylomannan delays translocation of leukocytes across the blood-brain barrier in an animal model of acute bacterial meningitis

被引：25

作者：

Lipovsky, MM

Tsenova, L

Coenjaerts, FEJ

Kaplan, G

Cherniak, R

Hoepelman, AIM

机构：

[1] Univ Utrecht, Med Ctr, Eijkman Winkler Inst, Div Infect Dis & AIDS,Dept Med, NL-3508 GA Utrecht, Netherlands

[2] Rockefeller Univ, Cellular Physiol & Immunol Lab, New York, NY 10021 USA

[3] Georgia State Univ, Dept Chem, Lab Biol & Chem Sci, Atlanta, GA 30303 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 111卷 / 1-2期

关键词：

bacterial meningitis; leukocytes; GXM; inflammation;

D O I：

10.1016/S0165-5728(00)00354-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In bacterial meningitis, neurological damage is associated with a high influx of polymorphonuclear leukocytes (PMN) into the brain. Previous data suggest that the capsular component of the fungus C. neoformans, glucuronoxylomannan (GXM), interferes with PMN-migration into the cerebrospinal fluid (CSF). Therefore, a rabbit model of bacterial meningitis was treated intravenously with GXM. This resulted in (1) a reduction of PMN in the CSF at 6 h (P=0.05), (2) reduced peak TNF-alpha concentrations in the CSF, and (3) diminished tissue inflammation and intravascular margination of PMN in GXM-treated animals. Thus, GXM may represent a novel adjuvant anti-inflammatory agent in bacterial meningitis. (C) 2000 Published by Elsevier Science B.V.

引用

页码：10 / 14

页数：5

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