Roles of Microvesicles in Tumor Progression and Clinical Applications

被引：36
|
作者：
Zhu, Shuangli [1 ]
Li, Shiyu [1 ]
Yi, Ming [1 ]
Li, Ning [2 ,3 ]
Wu, Kongmin [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, Wuhan 430030, Peoples R China
[2] Zhengzhou Univ, Affiliated Canc Hosp, Dept Med Oncol, Zhengzhou 450008, Peoples R China
[3] Henan Canc Hosp, Zhengzhou 450008, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2021年 / 16卷
基金：
中国国家自然科学基金;
关键词：
tumor-derived microvesicles; metastasis; drug resistance; cancer vaccine; cancer; CELL-DERIVED MICROVESICLES; BREAST-CANCER INVASION; MEMBRANE-VESICLES; EXTRACELLULAR VESICLES; P-GLYCOPROTEIN; FAS LIGAND; RELEASED MICROVESICLES; ENDOTHELIAL EXPRESSION; INTERCELLULAR TRANSFER; PROMOTE ANGIOGENESIS;
D O I：
10.2147/IJN.S325448
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Microvesicles are extracellular vesicles with diameter ranging from 100 to 1000 nm that are secreted by tumor cells or other cells in the tumor microenvironment. A growing number of studies demonstrate that tumor-derived microvesicles are involved in tumor initiation and progression, as well as drug resistance. In addition, tumor-derived microvesicles carry a variety of immunogenic molecules and inhibit tumor response to immunotherapy; therefore, they can be exploited for use in tumor vaccines. Moreover, because of their high stability, tumor-derived microvesicles extracted from body fluids can be used as biomarkers for cancer diagnosis or assessment of prognosis. Tumor-derived microvesicles can also be deployed to reverse drug resistance of tumor regenerative cells, or to deliver chemotherapeutic drugs and oncolytic adenovirus for the treatment of cancer patients. This review summarizes the general characteristics of tumor-derived microvesicles, focusing on their biological characteristics, their involvement in tumor progression, and their clinical applications.
引用
收藏
页码：7071 / 7090
页数：20
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