The Emerging Roles of Exosomal miRNAs in Breast Cancer Progression and Potential Clinical Applications

被引:4
|
作者
Li, Jie [1 ]
He, Dejiao [2 ]
Bi, Yajun [3 ]
Liu, Shengxuan [4 ]
机构
[1] Shenzhen Qianhai Shekou Free Trade Zone Hosp, Dept Thyroid & Breast Surg, Shenzhen, Peoples R China
[2] Wuhan Univ, Dept Nephrol, Renmin Hosp, Wuhan 430060, Peoples R China
[3] Dalian Med Univ, Dalian Municipal Women & Childrens Med Ctr Grp, Dept Pediat, Dalian 116011, Liaoning, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan 430030, Hubei, Peoples R China
来源
关键词
breast cancer; tumor microenvironment; exosome; miRNAs; detection; therapy; PROMOTES; CELLS; METASTASIS; RESISTANCE; MACROPHAGES; MICRORNAS; IDENTIFICATION; PROLIFERATION; CHEMOTHERAPY; FIBROBLASTS;
D O I
10.2147/BCTT.S432750
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer remains the leading malignancy in terms of morbidity and mortality today. The tumor microenvironment of breast cancer includes multiple cell types, secreted proteins, and signaling components such as exosomes. Among these, exosomes have a lipid bilayer structure. Exosomes can reflect the biological traits of the parent cell and carry a variety of biologically active components, including proteins, lipids, small molecules, and non-coding RNAs, which include miRNA, lncRNA, and circRNA. MiRNAs are a group of non-coding RNAs of approximately 20-23 nucleotides in length encoded by the genome, triggering silencing and functional repression of target genes. MiRNAs have been shown to play a significant role in the development of cancer owing to their role in the prognosis, pathogenesis, diagnosis, and treatment of cancer. MiRNAs in exosomes can serve as effective mediators of information transfer from parental cells to recipient cells and trigger changes in biological traits such as proliferation, invasion, migration, and drug resistance. These changes can profoundly alter the progression of breast cancer. Therefore, here, we systematically summarize the association of exosomal miRNAs on breast cancer progression, diagnosis, and treatment in the hope of providing novel strategies and directions for subsequent breast cancer treatment.
引用
收藏
页码:825 / 840
页数:16
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