Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for In Vivo Cancer Treatment

被引：308

作者：

Chen, Hongmin ^{[1
,2
,3
,4
]}

Wang, Geoffrey D. ^{[1
]}

Chuang, Yen-Jun ^{[5
]}

Zhen, Zipeng ^{[1
,2
]}

Chen, Xiaoyuan ^{[6
]}

Biddinger, Paul ^{[7
]}

Hao, Zhonglin ^{[8
]}

Liu, Feng ^{[5
]}

Shen, Baozhong ^{[3
,4
]}

Pan, Zhengwei ^{[5
]}

Xie, Jin ^{[1
,2
]}

机构：

[1] Univ Georgia, Dept Chem, Athens, GA 30602 USA

[2] Univ Georgia, Bioimaging Res Ctr, Athens, GA 30602 USA

[3] Harbin Med Univ, Hosp 4, Dept Radiol, Harbin 157, Peoples R China

[4] Harbin Med Univ, Mol Imaging Res Ctr, Harbin 157, Peoples R China

[5] Univ Georgia, Coll Engn, Athens, GA 30602 USA

[6] Natl Inst Biomed Imaging & Bioengn, NIH, Rockville, MD 20852 USA

[7] Georgia Regents Univ, Dept Pathol, Augusta, GA 30912 USA

[8] Georgia Regents Univ, Dept Internal Med, Med Coll Georgia, Augusta, GA 30912 USA

来源：

NANO LETTERS | 2015年 / 15卷 / 04期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

nanomedicine; X-PDT; nanoscintillator; radioluminescence nanophosphors; singlet oxygen; cancer treatment; UP-CONVERSION NANOPARTICLES; RETICULOENDOTHELIAL SYSTEM CLEARANCE; MESOPOROUS SILICA; LIGHT; LUMINESCENCE; IRRADIATION; ALUMINATE; RADIATION; BIOLOGY; EU2+;

D O I：

10.1021/nl504044p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photodynamic therapy is a promising :treatment method, but its applications are limited by the shallow penetration of visible light Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach That allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a Core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

引用

页码：2249 / 2256

页数：8

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