Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for In Vivo Cancer Treatment

被引：308

作者：

Chen, Hongmin ^{[1
,2
,3
,4
]}

Wang, Geoffrey D. ^{[1
]}

Chuang, Yen-Jun ^{[5
]}

Zhen, Zipeng ^{[1
,2
]}

Chen, Xiaoyuan ^{[6
]}

Biddinger, Paul ^{[7
]}

Hao, Zhonglin ^{[8
]}

Liu, Feng ^{[5
]}

Shen, Baozhong ^{[3
,4
]}

Pan, Zhengwei ^{[5
]}

Xie, Jin ^{[1
,2
]}

机构：

[1] Univ Georgia, Dept Chem, Athens, GA 30602 USA

[2] Univ Georgia, Bioimaging Res Ctr, Athens, GA 30602 USA

[3] Harbin Med Univ, Hosp 4, Dept Radiol, Harbin 157, Peoples R China

[4] Harbin Med Univ, Mol Imaging Res Ctr, Harbin 157, Peoples R China

[5] Univ Georgia, Coll Engn, Athens, GA 30602 USA

[6] Natl Inst Biomed Imaging & Bioengn, NIH, Rockville, MD 20852 USA

[7] Georgia Regents Univ, Dept Pathol, Augusta, GA 30912 USA

[8] Georgia Regents Univ, Dept Internal Med, Med Coll Georgia, Augusta, GA 30912 USA

来源：

NANO LETTERS | 2015年 / 15卷 / 04期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

nanomedicine; X-PDT; nanoscintillator; radioluminescence nanophosphors; singlet oxygen; cancer treatment; UP-CONVERSION NANOPARTICLES; RETICULOENDOTHELIAL SYSTEM CLEARANCE; MESOPOROUS SILICA; LIGHT; LUMINESCENCE; IRRADIATION; ALUMINATE; RADIATION; BIOLOGY; EU2+;

D O I：

10.1021/nl504044p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photodynamic therapy is a promising :treatment method, but its applications are limited by the shallow penetration of visible light Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach That allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a Core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

引用

页码：2249 / 2256

页数：8

共 50 条

[31] Cancer treatment by X-ray holography
MadjidiZolbanine, H
Jafari, SS
LASERS IN MEDICINE AND DENTISTRY: DIAGNOSTICS AND TREATMENT, 1996, 2887 : 84 - 90
[32] Treatment of Oral Candidiasis Using Photodithazine®-Mediated Photodynamic Therapy In Vivo
Carmello, Juliana Cabrini
Alves, Fernanda
Basso, Fernanda G.
de Souza Costa, Carlos Alberto
Bagnato, Vanderlei Salvador
de Oliveira Mima, Ewerton Garcia
Pavarina, Ana Claudia
PLOS ONE, 2016, 11 (06):
[33] Surface modified nanoparticles for photoimmunotherapy and X-ray induced photodynamic therapy
Xie, Jin
Zhen, Zipeng
Zhou, Shiyi
Chen, Hongmin
Zhang, Weizhong
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
[34] Adjunctive effects with continual X-ray irradiation for effective photodynamic therapy
Ito, Hiromu
Nakanishi, Ikuo
FREE RADICAL BIOLOGY AND MEDICINE, 2022, 192
[35] Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy
Kirakci, Kaplan
Zelenka, Jaroslav
Rumlova, Michaela
Martincik, Jiri
Nikl, Martin
Ruml, Tomas
Lang, Kamil
JOURNAL OF MATERIALS CHEMISTRY B, 2018, 6 (26) : 4301 - 4307
[36] X-RAY THERAPY IN TREATMENT OF SUPRATENTORIAL GLIOMAS
FRAZER, AK
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1972, 35 (06): : 924 - 925
[37] The treatment of acute eczema with X-ray therapy
Bormann, S
ARCHIV FUR DERMATOLOGIE UND SYPHILIS, 1925, 149 (03): : 519 - 524
[38] THE TREATMENT OF HYPERNEPHROMA BY NEPHRECTOMY AND X-RAY THERAPY
BRATHERTON, DG
BRITISH JOURNAL OF RADIOLOGY, 1963, 36 (428): : 615 - 615
[39] PROPHYLAXIS AND THERAPY OF COMPLICATIONS IN X-RAY TREATMENT
SAUER, R
FORTSCHRITTE DER MEDIZIN, 1980, 98 (19) : 736 - 739
[40] THE TREATMENT OF AMENORRHEA AND STERILITY BY X-RAY THERAPY
KAPLAN, II
WOLFE, SA
NEW YORK STATE JOURNAL OF MEDICINE, 1946, 46 (24) : 2746 - 2752

← 1 2 3 4 5 →