Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for In Vivo Cancer Treatment

被引：308

作者：

Chen, Hongmin ^{[1
,2
,3
,4
]}

Wang, Geoffrey D. ^{[1
]}

Chuang, Yen-Jun ^{[5
]}

Zhen, Zipeng ^{[1
,2
]}

Chen, Xiaoyuan ^{[6
]}

Biddinger, Paul ^{[7
]}

Hao, Zhonglin ^{[8
]}

Liu, Feng ^{[5
]}

Shen, Baozhong ^{[3
,4
]}

Pan, Zhengwei ^{[5
]}

Xie, Jin ^{[1
,2
]}

机构：

[1] Univ Georgia, Dept Chem, Athens, GA 30602 USA

[2] Univ Georgia, Bioimaging Res Ctr, Athens, GA 30602 USA

[3] Harbin Med Univ, Hosp 4, Dept Radiol, Harbin 157, Peoples R China

[4] Harbin Med Univ, Mol Imaging Res Ctr, Harbin 157, Peoples R China

[5] Univ Georgia, Coll Engn, Athens, GA 30602 USA

[6] Natl Inst Biomed Imaging & Bioengn, NIH, Rockville, MD 20852 USA

[7] Georgia Regents Univ, Dept Pathol, Augusta, GA 30912 USA

[8] Georgia Regents Univ, Dept Internal Med, Med Coll Georgia, Augusta, GA 30912 USA

来源：

NANO LETTERS | 2015年 / 15卷 / 04期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

nanomedicine; X-PDT; nanoscintillator; radioluminescence nanophosphors; singlet oxygen; cancer treatment; UP-CONVERSION NANOPARTICLES; RETICULOENDOTHELIAL SYSTEM CLEARANCE; MESOPOROUS SILICA; LIGHT; LUMINESCENCE; IRRADIATION; ALUMINATE; RADIATION; BIOLOGY; EU2+;

D O I：

10.1021/nl504044p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photodynamic therapy is a promising :treatment method, but its applications are limited by the shallow penetration of visible light Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach That allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a Core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

引用

页码：2249 / 2256

页数：8

共 50 条

[1] Nanoscintillator-Mediated X-Ray Induced Photodynamic Therapy for Deep-Seated Tumors: From Concept to Biomedical Applications
Sun, Wenjing
Zhou, Zijian
Pratx, Guillem
Chen, Xiaoyuan
Chen, Hongmin
THERANOSTICS, 2020, 10 (03): : 1296 - 1318
[2] Pure Organic AIE Nanoscintillator for X-ray Mediated Type I and Type II Photodynamic Therapy
Yu, Yuewen
Xiang, Lisha
Zhang, Xuanwei
Zhang, Le
Ni, Zhiqiang
Zhu, Zhong-Hong
Liu, Yubo
Lan, Jie
Liu, Wei
Xie, Ganfeng
Feng, Guangxue
Tang, Ben Zhong
ADVANCED SCIENCE, 2023, 10 (26)
[3] Optimized scintillator YAG:Pr nanoparticles for X-ray inducible photodynamic therapy
Sapre, Ajay A.
Novitskaya, Ekaterina
Vakharia, Ved
Cota, Alejandro
Wrasidlo, Wolfgang
Hanrahan, Stephen M.
Derenzo, Stephen
Makale, Milan T.
Graeve, Olivia A.
MATERIALS LETTERS, 2018, 228 : 49 - 52
[4] Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy
Wang, Xiao
Sun, Wenjing
Shi, Huifang
Ma, Huili
Niu, Guowei
Li, Yuxin
Zhi, Jiahuan
Yao, Xiaokang
Song, Zhicheng
Chen, Lei
Li, Shi
Yang, Guohui
Zhou, Zixing
He, Yixiao
Qu, Shuli
Wu, Min
Zhao, Zhu
Yin, Chengzhu
Lin, Chongyang
Gao, Jia
Li, Qiuying
Zhen, Xu
Li, Lin
Chen, Xiaoyuan
Liu, Xiaogang
An, Zhongfu
Chen, Hongmin
Huang, Wei
NATURE COMMUNICATIONS, 2022, 13 (01)
[5] Nanocomposites for X-Ray Photodynamic Therapy
Gadzhimagomedova, Zaira
Zolotukhin, Peter
Kit, Oleg
Kirsanova, Dania
Soldatov, Alexander
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (11)
[6] Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy
Xiao Wang
Wenjing Sun
Huifang Shi
Huili Ma
Guowei Niu
Yuxin Li
Jiahuan Zhi
Xiaokang Yao
Zhicheng Song
Lei Chen
Shi Li
Guohui Yang
Zixing Zhou
Yixiao He
Shuli Qu
Min Wu
Zhu Zhao
Chengzhu Yin
Chongyang Lin
Jia Gao
Qiuying Li
Xu Zhen
Lin Li
Xiaoyuan Chen
Xiaogang Liu
Zhongfu An
Hongmin Chen
Wei Huang
Nature Communications, 13
[7] X-Ray Induced Photodynamic Therapy: A Combination of Radiotherapy and Photodynamic Therapy
Wang, Geoffrey D.
Nguyen, Ha T.
Chen, Hongmin
Cox, Phillip B.
Wang, Lianchun
Nagata, Koichi
Hao, Zhonglin
Wang, Andrew
Li, Zibo
Xie, Jin
THERANOSTICS, 2016, 6 (13): : 2295 - 2305
[8] Nanoscintillator-Mediated X-Ray-Triggered Boosting Transformation of Fe3+ into Fe2+ for Enhancing Tumor Ferroptosis/Immunotherapy
Zhang, Caiju
Lu, Shuting
Deng, Kai
Qian, Wang
Liu, Yue
Li, Yi
Jin, Shiqi
Suo, Ruiyang
Xu, Haibo
Wu, Bo
ADVANCED FUNCTIONAL MATERIALS, 2023,
[9] Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications
Wang, Lei
Meng, Dehui
Hao, Yongwei
Zhao, Yalin
Li, Dong
Zhang, Bingxiang
Zhang, Yun
Zhang, Zhenzhong
JOURNAL OF BIOMATERIALS APPLICATIONS, 2015, 30 (05) : 547 - 557
[10] Nanoscintillator-Mediated X-Ray-Triggered Boosting Transformation of Fe3+ into Fe2+ for Enhancing Tumor Ferroptosis/Immunotherapy
Zhang, Caiju
Lu, Shuting
Deng, Kai
Qian, Wang
Liu, Yue
Li, Yi
Jin, Shiqi
Suo, Ruiyang
Xu, Haibo
Wu, Bo
ADVANCED FUNCTIONAL MATERIALS, 2023, 33 (45)

← 1 2 3 4 5 →