Extreme neonatal hyperbilirubinemia and kernicterus spectrum disorder in Denmark during the years 2000-2015

被引:35
|
作者
Donneborg, Mette Line [1 ,2 ]
Hansen, Bo Moelholm [3 ]
Vandborg, Pernille Kure [1 ]
Rodrigo-Domingo, Maria [4 ,5 ]
Ebbesen, Finn [1 ,2 ]
机构
[1] Aalborg Univ Hosp, Dept Pediat, Aalborg, Denmark
[2] Aalborg Univ, Dept Clin Med, Aalborg, Denmark
[3] Herlev Hosp, Dept Pediat, Copenhagen, Denmark
[4] Aalborg Univ Hosp, Unit Epidemiol & Biostat, Aalborg, Denmark
[5] Aalborg Univ Hosp, Psychiat, Aalborg, Denmark
关键词
NEAR-TERM INFANTS; SERUM BILIRUBIN; FOLLOW-UP; PROSPECTIVE SURVEILLANCE; NEWBORN; GUIDELINES; MANAGEMENT; ENCEPHALOPATHY; PREVENTION; HEMOLYSIS;
D O I
10.1038/s41372-019-0566-8
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective To determine the incidence and etiology of extreme neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) >= 450 mu mol/L, and kernicterus spectrum disorder (KSD) in Denmark between 2000 and 2015. Study design We identified all infants born between 01.01.2000 and 31.12.2015 with TSB >= 450 mu mol/L, ratio of conjugated to TSB <0.30, gestational age >= 35 weeks, and postnatal age <= 4 weeks, using Danish hospitals' laboratory databases. Result We included 408 infants. The incidence of extreme neonatal hyperbilirubinemia among infants with gestational age >= 35 weeks was 42/100,000 during the study period with a seemingly decreasing incidence between 2005 and 2015. Twelve of the 408 infants developed KSD, (incidence 1.2/100,000) Blood type ABO isohemolytic disease was the most common explanatory etiology. Conclusions Our study stresses the importance of a systematic approach to neonatal jaundice and ongoing surveillance of extreme neonatal hyperbilirubinemia and KSD.
引用
收藏
页码:194 / 202
页数:9
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