Rational molecular design and EPC synthesis of a type VI β-turn inducing peptide mimetic

被引：0

作者：

Hoffmann, T

Lanig, H

Waibel, R

Gmeiner, P

机构：

[1] Univ Erlangen Nurnberg, Comp Chem Ctr, D-91052 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Dept Med Chem, Emil Fischer Ctr, D-91052 Erlangen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 18期

关键词：

D O I：

10.1002/1521-3773(20010917)40:18<3361::AID-ANIE3361>3.0.CO;2-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A fruitful combination of molecular dynamics based design and modern synthetic reactions led to a conformatively rigidized cis-peptidyl proline surrogate (see picture). NMR spectroscopic experiments clearly show the existance of type VIa β-turn properties that are of interest in drug discovery.

引用

页码：3361 / +

页数：5

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