DESIGN, SYNTHESIS AND EVALUATION OF A NOVEL BICYCLIC LACTAM AS A GLY-PRO TYPE-VI BETA-TURN MIMIC

被引：0

作者：

DUMAS, JP ^{[1
]}

GERMANAS, JP ^{[1
]}

机构：

[1] UNIV HOUSTON,DEPT CHEM,HOUSTON,TX 77204

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 10期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective synthesis and conformational evaluation of Gly-Pro type VI turn mimic 7, the first mimetic to constrain the central three bonds and incorporate the side chain groups of a beta-turn, is described. A superimposition of the crystallographically determined structure of 7 with the structure of a typical type VI turn revealed exceptional similarity in backbone and side chain atom positions. The temperature dependence of the chemical shift of the amide proton of the derivative 8 in DMSO confirmed the presence of a remarkably stable i, i+3 intramolecular hydrogen bond.

引用

页码：1493 / 1496

页数：4

共 27 条

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