Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine

被引：36

作者：

Gentile, Giovanna ^{[1
]}

Borro, Marina ^{[2
]}

Lala, Noemi ^{[3
]}

Missori, Serena ^{[3
]}

Simmaco, Maurizio ^{[2
]}

Martelletti, Paolo ^{[3
]}

机构：

[1] Univ Roma La Sapienza, St Andrea Hosp, Sch Med 2, Dept Biochem Sci,Adv Mol Diagnost Unit, I-00189 Rome, Italy

[2] Univ Roma La Sapienza, St Andrea Hosp, Sch Med 2, NESMOS Dept,Adv Mol Diagnost Unit, I-00189 Rome, Italy

[3] Univ Roma La Sapienza, St Andrea Hosp, Sch Med 2, Dept Med & Mol Sci,Reg Referral Headache Ctr, I-00189 Rome, Italy

来源：

JOURNAL OF HEADACHE AND PAIN | 2010年 / 11卷 / 05期

关键词：

Chronic migraine; SNPs; Triptan overuse; Triptan efficacy; Polymorphisms; CRITERIA; HEADACHE;

D O I：

10.1007/s10194-010-0241-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Migraine is a common type of headache and its most severe attacks are usually treated with triptans, the efficacy of which is extremely variable. Several SNPs in genes involved in metabolism and target mechanisms of triptans have been described. To define an association between genetic profile and triptan response, we classified a migrainous population on the basis of triptan response and characterized it for polymorphisms in the genes coding for monoamine oxidase A, G protein beta 3 and the cytochrome CYP1A2. Analysis of the association between genotypic and allelic frequencies of the analyzed SNPs and the grade of response to triptan administration showed a significant correlation for MAOA uVNTR polymorphism. Further stratification of patients in abuser and non-abuser groups revealed a significant association with triptan overuse and, within the abusers, with drug response to the CYP1A2*1F variant.

引用

页码：431 / 435

页数：5

共 50 条

[41] Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks
Rubino, Elisa
Marcinno, Andrea
Grassini, Alberto
Piella, Elisa Maria
Ferrandes, Fabio
Roveta, Fausto
Boschi, Silvia
Cermelli, Aurora
Gallone, Salvatore
Savi, Lidia
Rainero, Innocenzo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (01)
[42] Early dosing and efficacy of triptans in acute migraine treatment: the TEMPO study
Lanteri-Minet, M.
Mick, G.
Allaf, B.
CEPHALALGIA, 2012, 32 (03) : 226 - 235
[43] The journey from genetic predisposition to medication overuse headache to its acquisition as sequela of chronic migraine
Martelletti, Paolo
JOURNAL OF HEADACHE AND PAIN, 2018, 19
[44] The journey from genetic predisposition to medication overuse headache to its acquisition as sequela of chronic migraine
Paolo Martelletti
The Journal of Headache and Pain, 2018, 19
[45] The Migraine Intervention Score - a tool to improve efficacy of triptans in acute migraine therapy: the ALADIN study
Goebel, H.
Heinze, A.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2011, 65 (08) : 879 - 886
[46] Do migraine preventive medications enhance the efficacy of triptans? Analyses from topiramate migraine trials
Dodick, D
Hulihan, J
Wu, SC
CEPHALALGIA, 2004, 24 (09) : 808 - 808
[47] Do migraine preventive medications enhance the efficacy of triptans? Analyses from topiramate migraine trials
Dodick, D
Hulihan, J
Wu, S
HEADACHE, 2005, 45 (06): : 820 - 820
[48] Efficacy, tolerability, and health care costs of triptans for acute migraine treatment
Mannix, LK
HEADACHE QUARTERLY-CURRENT TREATMENT AND RESEARCH, 2002, 13 (01): : 19 - 24
[49] Degradation of endocannabinoids in chronic migraine and medication overuse headache
Cupini, L. M.
Costa, C.
Sarchielli, P.
Bari, M.
Battista, N.
Eusebi, P.
Calabresi, P.
Maccarrone, M.
NEUROBIOLOGY OF DISEASE, 2008, 30 (02) : 186 - 189
[50] Multimorbidity in patients with chronic migraine and medication overuse headache
D'Amico, Domenico
Sansone, Emanuela
Grazzi, Licia
Giovannetti, Ambra M.
Leonardi, Matilde
Schiavolin, Silvia
Raggi, Alberto
ACTA NEUROLOGICA SCANDINAVICA, 2018, 138 (06): : 515 - 522

← 1 2 3 4 5 →