Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine

被引:36
|
作者
Gentile, Giovanna [1 ]
Borro, Marina [2 ]
Lala, Noemi [3 ]
Missori, Serena [3 ]
Simmaco, Maurizio [2 ]
Martelletti, Paolo [3 ]
机构
[1] Univ Roma La Sapienza, St Andrea Hosp, Sch Med 2, Dept Biochem Sci,Adv Mol Diagnost Unit, I-00189 Rome, Italy
[2] Univ Roma La Sapienza, St Andrea Hosp, Sch Med 2, NESMOS Dept,Adv Mol Diagnost Unit, I-00189 Rome, Italy
[3] Univ Roma La Sapienza, St Andrea Hosp, Sch Med 2, Dept Med & Mol Sci,Reg Referral Headache Ctr, I-00189 Rome, Italy
来源
JOURNAL OF HEADACHE AND PAIN | 2010年 / 11卷 / 05期
关键词
Chronic migraine; SNPs; Triptan overuse; Triptan efficacy; Polymorphisms; CRITERIA; HEADACHE;
D O I
10.1007/s10194-010-0241-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Migraine is a common type of headache and its most severe attacks are usually treated with triptans, the efficacy of which is extremely variable. Several SNPs in genes involved in metabolism and target mechanisms of triptans have been described. To define an association between genetic profile and triptan response, we classified a migrainous population on the basis of triptan response and characterized it for polymorphisms in the genes coding for monoamine oxidase A, G protein beta 3 and the cytochrome CYP1A2. Analysis of the association between genotypic and allelic frequencies of the analyzed SNPs and the grade of response to triptan administration showed a significant correlation for MAOA uVNTR polymorphism. Further stratification of patients in abuser and non-abuser groups revealed a significant association with triptan overuse and, within the abusers, with drug response to the CYP1A2*1F variant.
引用
收藏
页码:431 / 435
页数:5
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