Association between depressed mood in the elderly and a 5-HTR2A gene variant

被引：44
|
作者：
Jansson, M
Gatz, M
Berg, S
Johansson, B
Malmberg, B
McClearn, GE
Schalling, M
Pedersen, NL
机构：
[1] Karolinska Inst, Dept Med Epidemiol, S-17177 Stockholm, Sweden
[2] Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA
[3] Jonkoping Univ, Inst Gerontol, Jonkoping, Sweden
[4] Gothenburg Univ, Dept Psychol, Gothenburg, Sweden
[5] Penn State Univ, Ctr Dev & Hlth Genet, University Pk, PA 16802 USA
[6] Karolinska Inst, Dept Mol Med, Stockholm, Sweden
[7] Karolinska Sjukhuset, Stockholm, Sweden
来源：
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2003年 / 120B卷 / 01期
关键词：
serotonin; depressed mood; SNP;
D O I：
10.1002/ajmg.b.20016
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The aim of this study was to investigate any possible association between depressed mood in the elderly and two candidate SNPs in the serotonin system: one in the 5-HTR2A gene promotor (-1438 G/A) and one in the 5-HT transporter gene (-925 C/A). DNA from a population-based Swedish twin sample (N = 1,592; mean age = 73) was genotyped using Pryosequencing(TM). An association was found between the 5-HTR2A gene promotor polymorphism and depressed mood (OR: 1.5, Cl: 1.1-2.1) for the A/A genotype in the total sample. When the sample was analyzed by gender, a significant association (OR: 2.4, Cl: 1.4-4.4) was found for males and the A/A genotype, but not for females. The 5-HT transporter gene was not associated with depressed mood in this elderly population. These results suggest that there might be different genetic mechanisms for males and females contributing to the development of depressed mood in the elderly. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码：79 / 84
页数：6
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