Association between depressed mood in the elderly and a 5-HTR2A gene variant

被引：44
|
作者：
Jansson, M
Gatz, M
Berg, S
Johansson, B
Malmberg, B
McClearn, GE
Schalling, M
Pedersen, NL
机构：
[1] Karolinska Inst, Dept Med Epidemiol, S-17177 Stockholm, Sweden
[2] Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA
[3] Jonkoping Univ, Inst Gerontol, Jonkoping, Sweden
[4] Gothenburg Univ, Dept Psychol, Gothenburg, Sweden
[5] Penn State Univ, Ctr Dev & Hlth Genet, University Pk, PA 16802 USA
[6] Karolinska Inst, Dept Mol Med, Stockholm, Sweden
[7] Karolinska Sjukhuset, Stockholm, Sweden
来源：
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2003年 / 120B卷 / 01期
关键词：
serotonin; depressed mood; SNP;
D O I：
10.1002/ajmg.b.20016
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The aim of this study was to investigate any possible association between depressed mood in the elderly and two candidate SNPs in the serotonin system: one in the 5-HTR2A gene promotor (-1438 G/A) and one in the 5-HT transporter gene (-925 C/A). DNA from a population-based Swedish twin sample (N = 1,592; mean age = 73) was genotyped using Pryosequencing(TM). An association was found between the 5-HTR2A gene promotor polymorphism and depressed mood (OR: 1.5, Cl: 1.1-2.1) for the A/A genotype in the total sample. When the sample was analyzed by gender, a significant association (OR: 2.4, Cl: 1.4-4.4) was found for males and the A/A genotype, but not for females. The 5-HT transporter gene was not associated with depressed mood in this elderly population. These results suggest that there might be different genetic mechanisms for males and females contributing to the development of depressed mood in the elderly. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码：79 / 84
页数：6
相关论文
共 50 条
  • [11] Temperament in childhood as a predictor of Harm Avoidance in adulthood: Moderation by the 5-HTR2A gene
    Pulkki-Raback, Laura
    Merjonen, Paivi
    Jokela, Markus
    Salo, Johanna
    Lehtimaki, Terho
    INTERNATIONAL JOURNAL OF PSYCHOLOGY, 2008, 43 (3-4) : 362 - 363
  • [12] Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
    Yucel, Yavuz
    Coskun, Salih
    Cengiz, Beyhan
    Ozdemir, Hasan H.
    Uzar, Ertugrul
    Cim, Abdullah
    Camkurt, M. Akif
    Aluclu, M. Ufuk
    CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, 2016, 14 (03) : 250 - 255
  • [13] Mood disorders and 5-HTR2A genetic variants - the moderator effect of inflammation on expression of affective polarity phenotype
    Pantovic-Stefanovic, Maja
    Karanovic, Jelena
    Jurisic, Vladimir
    Dunjic-Kostic, Bojana
    Nesic, Milica
    Dodic, Sara
    Gostiljac, Marta
    Puric, Marija
    Pavicevic, Dusanka Savic
    Ivkovic, Maja
    BMC PSYCHIATRY, 2024, 24 (01)
  • [14] An insight into the understanding of 5-HTR2A variants leading to schizophrenia
    Lingaiah, Kusuma
    Ramachandra, Nallur B.
    INDIAN JOURNAL OF MEDICAL RESEARCH, 2014, 140 : 713 - 715
  • [15] Serotonin receptor gene 5-HTR2A polymorphism and schizotypic traits in mentally healthy subjects
    Mityushina, NG
    Alfimova, MV
    Lyashenko, GL
    Asanov, AY
    Golimbet, VE
    ZHURNAL NEVROPATOLOGII I PSIKHIATRII IMENI S S KORSAKOVA, 2003, 103 (11): : 53 - 57
  • [16] Polymorphism of the serotonin receptor type 2A (5-HTR2A) gene and verbal fluency in normalcy and in schizophrenia
    Alfimova, MV
    Golimbet, VE
    Mityushina, NG
    MOLECULAR BIOLOGY, 2003, 37 (01) : 62 - 66
  • [17] Polymorphism of the Serotonin Receptor Type 2A (5-HTR2A) Gene and Verbal Fluency in Normalcy and in Schizophrenia
    M. V. Alfimova
    V. E. Golimbet
    N. G. Mityushina
    Molecular Biology, 2003, 37 : 62 - 66
  • [18] 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression
    Illi, Ari
    Setala-Soikkeli, Eija
    Viikki, Merja
    Poutanen, Outi
    Huhtala, Heini
    Mononen, Nina
    Lehtimaki, Terho
    Leinonen, Esa
    Kampman, Olli
    NEUROREPORT, 2009, 20 (12) : 1125 - 1128
  • [19] Analysis of Associations between 5-HTT, 5-HTR2A, and GABRA6 Gene Polymorphisms and Health-Associated Personality Traits
    Alfimova, M. V.
    Monakhov, M. V.
    Golimbet, V. E.
    Korovaitseva, G. I.
    Lyashenko, G. L.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2010, 149 (04) : 434 - 436
  • [20] A-1438-G serotonin receptor type 2A (5-HTR2A) gene polymorphism in patients with schizophrenia
    Mityushina, NG
    Abramova, LI
    Kaleda, VG
    Golimbet, VE
    ZHURNAL NEVROPATOLOGII I PSIKHIATRII IMENI S S KORSAKOVA, 2003, 103 (03): : 43 - 46
12345