Microbiota-gut-brain axis: A novel potential target of ketogenic diet for epilepsy

被引：13
|
作者：
Tang, Yong [1 ]
Wang, Qi [2 ]
Liu, Jie [3 ,4 ]
机构：
[1] Chengdu Sports Univ, Chengdu, Peoples R China
[2] Southwest Med Univ, Luzhou, Peoples R China
[3] Sichuan Acad Med Sci, Chengdu, Peoples R China
[4] Sichuan Prov Peoples Hosp, Chengdu, Peoples R China
来源：
CURRENT OPINION IN PHARMACOLOGY | 2021年 / 61卷
关键词：
MECHANISMS; STRESS;
D O I：
10.1016/j.coph.2021.08.018
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ketogenic diet (KD) has been used to the control of seizure for 100 years because it was developed for the treatment of epi-lepsy in 1921. Based on current research on the microbiota-gut-brain axis to explore the new communication tool between gut bacteria and the brain and the progress of microbiota-gut-brain axis and KD for the treatment of epilepsy, the role of neurotransmitters adenosine and g-aminobutyric acid in the epileptic brain, we propose that the balance between beneficial and harmful bacteria in the gut microbiota would be a promising target in the future to underlying the working mechanism of KD for epilepsy.
引用
收藏
页码：36 / 41
页数：6
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