Microbiota-gut-brain axis: A novel potential target of ketogenic diet for epilepsy

Ketogenic diet (KD) has been used to the control of seizure for 100 years because it was developed for the treatment of epi-lepsy in 1921. Based on current research on the microbiota-gut-brain axis to explore the new communication tool between gut bacteria and the brain and the progress of microbiota-gut-brain axis and KD for the treatment of epilepsy, the role of neurotransmitters adenosine and g-aminobutyric acid in the epileptic brain, we propose that the balance between beneficial and harmful bacteria in the gut microbiota would be a promising target in the future to underlying the working mechanism of KD for epilepsy.