Triterpene glycosides with stimulatory activity on melanogenesis from the aerial parts of Weigela subsessilis

被引：14
|
作者：
Won, Yu-Mi [1 ,2 ]
Seong, Zuh-Kyung [1 ,2 ]
Kim, Jae-Lim [1 ,2 ]
Kim, Hui-Seong [3 ]
Song, Hyuk-Hwan [2 ]
Kim, Doo-Young [2 ]
Kim, Jung-Hee [2 ]
Oh, Sei-Ryang [2 ]
Cho, Hyun-Woo [4 ]
Cho, Jung-Hee [4 ]
Lee, Hyeong-Kyu [1 ,2 ]
机构：
[1] Univ Sci & Technol, Biomol Sci, Taejon 305806, South Korea
[2] Korea Res Inst Biosci & Biotechnol, Nat Med Res Ctr, Cheongju 363883, South Korea
[3] Korea Natl Inst Hlth, Ctr Immunol & Pathol, Div Aids, Cheongju 363951, South Korea
[4] Jeonnam Dev Inst Korean Tradit Med, Jangheung Gun, Jeonnam, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2015年 / 38卷 / 08期
关键词：
Weigela subsessilis; Caprifoliaceae; Melanogenesis stimulatory activity; Triterpene glycoside; Lonicerosides K-M; QUALITY-OF-LIFE; CLEMATIS-CHINENSIS; MELANOMA-CELLS; SAPONINS; VITILIGO; GLYCYRRHIZIN; CONSTITUENTS; IONIZATION; EXPRESSION; EXTRACTS;
D O I：
10.1007/s12272-014-0524-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new triterpene glycosides (Lonicerosides K, L and M) and 11 known compounds were isolated from the aerial parts of Weigela subsessilis. Among the known isolated compounds, loniceroside A, sweroside, kaempferol-3-O-glucopyranoside 6aEuro(3)-(3-hydroxy-3-methylglutarate), kaempferol-3-O-acetylglucoside and grandifloroside were reported for the first time in a Weigela genus plant. Their chemical structures were identified using extensive spectroscopic analysis including two-dimensional (2D)-NMR experiments, HR-ESI-QTOF-MS and comparison with reported data. Among these compounds, lonicerosides A and L had potent melanogenesis stimulatory activity in murine B16F0 melanoma cells. The structural relationship of active compounds was discussed.
引用
收藏
页码：1541 / 1551
页数：11
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