Triterpene glycosides from the aerial parts of Gouania longipetala

被引：5
|
作者：
Gossan, Diane Patricia Apie [1 ,2 ]
Magid, Abdulmagid Alabdul [1 ]
Yao-Kouassi, Philomene Akoua [2 ]
Coffy, Antoine Ahibo [2 ]
Josse, Jerome [3 ]
Gangloff, Sophie C. [3 ]
Morjani, Hamid [4 ]
Voutquenne-Nazabadioko, Laurence [1 ]
机构：
[1] ICMR UMR CNRS 7312, Grp Isolement & Struct, Campus Sci,Bat 18,BP 1039, F-51687 Reims, France
[2] Univ Felix Houphouet Boigny Abidjan Cocody, Lab Chim Organ & Subst Nat, 22 BP 582, Abidjan 22, Cote Ivoire
[3] UFR Pharm, Lab Microbiol, Biomat & Inflammat Site Osseux, EA 4691, 1 Rue Marechal Juin, F-51096 Reims, France
[4] URCA, SFR CAP Sante, Fac Pharm, MEDyC UMR CNRS 7369, 1 Rue Marechal Juin, F-51096 Reims, France
来源：
PHYTOCHEMISTRY | 2017年 / 134卷
关键词：
Gouania longipetala; Rhamnaceae; Triterpenoids; Antibacterial activity; Cytotoxic activity; CHEMICAL-CONSTITUENTS; DAMMARANE SAPONINS; ZIZYPHUS-LOTUS;
D O I：
10.1016/j.phytochem.2016.11.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Six previously undescribed triterpenoid saponins, gouaniaside I-VI, were isolated from the aerial parts of Gouania longipetala Hemsl. (Rhamnaceae), in addition to four known triterpenes. The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D- and 2D-NMR and HR-ESI-MS techniques. The inhibitory activity of isolated compounds against promyelocytic leukemia HL60 and human erythromyeloblastoid leukemia 1 < 562 cell lines was evaluated and jujuboside I exhibited moderate cytotoxicity, with IC50 values of 13.5 and 21.0 mu M, respectively. Among the isolated triterpenes, alphitolic acid exhibited moderate antibacterial activity against Staphylococcus aureus, Enterococcus faecalis and Escherichia coil (MICs 32, 64 and 128 mu g/mL, respectively). (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：71 / 77
页数：7
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