Metformin Exposure in the First Trimester of Pregnancy and Risk of All or Specific Congenital Anomalies: Exploratory Case-Control Study

被引：0
|
作者：
不详
机构：
[1] Administrative Data Research Centre Northern Ireland, Ulster University, Belfast
[2] Institute of Nursing and Health Research, Ulster University, Belfast
[3] Paediatric Department, Hospital Lillebaelt, Kolding
[4] Medical Genetics, CHUV, Lausanne
[5] University of Groningen, University Medical Center Groningen, Department of Genetics, Eurocat Northern Netherlands
[6] Registre des Malformations Congenitales de la Reunion, Saint-Pierre, Ile de la Reunion
[7] Health Information and Research, Guardamangia
[8] Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen
[9] Department of Global Public Health and Primary Care, University of Bergen, Bergen
[10] Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in Pregnancy, Paris Descartes University, Paris
[11] Congenital Anomaly Register and Information Service for Wales, Public Health Wales, Swansea
[12] IMER Registry (Emilia Romagna Registry of Birth Defects), University of Ferrara and Azienda Ospedaliero Universitaria di Ferrara, Ferrara
[13] Tuscany Registry of Congenital Defects, Institute of Clinical Physiology, National Research Council/Fondazione Toscana Gabriele Monasterio, Pisa
[14] Malformation Monitoring Centre Saxony-Anhalt, Medical Faculty Otto-von-Guericke University Magdeburg, Magdeburg
来源：
OBSTETRICAL & GYNECOLOGICAL SURVEY | 2018年 / 73卷 / 11期
关键词：
D O I：
10.1097/01.ogx.0000549829.99974.27
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
(Abstracted from BMJ 2018;361:k2477) Metformin affects stem cell function and has been shown to cross the human placenta at term, exposing the fetus to concentrations approaching those in the maternal circulation. Limited evidence from 3 meta-analyses and a cohort study suggests that the rate of all major congenital anomalies combined is not significantly increased after exposure to metformin.
引用
收藏
页码：619 / 620
页数：2
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