Metformin Exposure in the First Trimester of Pregnancy and Risk of All or Specific Congenital Anomalies: Exploratory Case-Control Study

被引：0

作者：

不详

机构：

[1] Administrative Data Research Centre Northern Ireland, Ulster University, Belfast

[2] Institute of Nursing and Health Research, Ulster University, Belfast

[3] Paediatric Department, Hospital Lillebaelt, Kolding

[4] Medical Genetics, CHUV, Lausanne

[5] University of Groningen, University Medical Center Groningen, Department of Genetics, Eurocat Northern Netherlands

[6] Registre des Malformations Congenitales de la Reunion, Saint-Pierre, Ile de la Reunion

[7] Health Information and Research, Guardamangia

[8] Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen

[9] Department of Global Public Health and Primary Care, University of Bergen, Bergen

[10] Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in Pregnancy, Paris Descartes University, Paris

[11] Congenital Anomaly Register and Information Service for Wales, Public Health Wales, Swansea

[12] IMER Registry (Emilia Romagna Registry of Birth Defects), University of Ferrara and Azienda Ospedaliero Universitaria di Ferrara, Ferrara

[13] Tuscany Registry of Congenital Defects, Institute of Clinical Physiology, National Research Council/Fondazione Toscana Gabriele Monasterio, Pisa

[14] Malformation Monitoring Centre Saxony-Anhalt, Medical Faculty Otto-von-Guericke University Magdeburg, Magdeburg

来源：

OBSTETRICAL & GYNECOLOGICAL SURVEY | 2018年 / 73卷 / 11期

关键词：

D O I：

10.1097/01.ogx.0000549829.99974.27

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

(Abstracted from BMJ 2018;361:k2477) Metformin affects stem cell function and has been shown to cross the human placenta at term, exposing the fetus to concentrations approaching those in the maternal circulation. Limited evidence from 3 meta-analyses and a cohort study suggests that the rate of all major congenital anomalies combined is not significantly increased after exposure to metformin.

引用

页码：619 / 620

页数：2

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