Metformin Exposure in the First Trimester of Pregnancy and Risk of All or Specific Congenital Anomalies: Exploratory Case-Control Study

被引：0

作者：

不详

机构：

[1] Administrative Data Research Centre Northern Ireland, Ulster University, Belfast

[2] Institute of Nursing and Health Research, Ulster University, Belfast

[3] Paediatric Department, Hospital Lillebaelt, Kolding

[4] Medical Genetics, CHUV, Lausanne

[5] University of Groningen, University Medical Center Groningen, Department of Genetics, Eurocat Northern Netherlands

[6] Registre des Malformations Congenitales de la Reunion, Saint-Pierre, Ile de la Reunion

[7] Health Information and Research, Guardamangia

[8] Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen

[9] Department of Global Public Health and Primary Care, University of Bergen, Bergen

[10] Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in Pregnancy, Paris Descartes University, Paris

[11] Congenital Anomaly Register and Information Service for Wales, Public Health Wales, Swansea

[12] IMER Registry (Emilia Romagna Registry of Birth Defects), University of Ferrara and Azienda Ospedaliero Universitaria di Ferrara, Ferrara

[13] Tuscany Registry of Congenital Defects, Institute of Clinical Physiology, National Research Council/Fondazione Toscana Gabriele Monasterio, Pisa

[14] Malformation Monitoring Centre Saxony-Anhalt, Medical Faculty Otto-von-Guericke University Magdeburg, Magdeburg

来源：

OBSTETRICAL & GYNECOLOGICAL SURVEY | 2018年 / 73卷 / 11期

关键词：

D O I：

10.1097/01.ogx.0000549829.99974.27

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

(Abstracted from BMJ 2018;361:k2477) Metformin affects stem cell function and has been shown to cross the human placenta at term, exposing the fetus to concentrations approaching those in the maternal circulation. Limited evidence from 3 meta-analyses and a cohort study suggests that the rate of all major congenital anomalies combined is not significantly increased after exposure to metformin.

引用

页码：619 / 620

页数：2

共 50 条

[1] Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control study
Given, Joanne E.
Loane, Maria
Garne, Ester
Addor, Marie-Claude
Bakker, Marian
Bertaut-Nativel, Benedicte
Gatt, Miriam
Klungsoyr, Kari
Lelong, Nathalie
Morgan, Margery
Neville, Amanda J.
Pierini, Anna
Rissmann, Anke
Dolk, Helen
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2018, 361
[2] Metformin exposure in first trimester of pregnancy does not increase risk of congenital anomalies
不详
[J]. BRITISH JOURNAL OF HOSPITAL MEDICINE, 2018, 79 (08) : 428 - 428
[3] Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case-control study
Leke, Aminkeng Zawuo
Dolk, Helen
Loane, Maria
Casson, Karen
Nelen, Vera
Barisic, Ingeborg
Garne, Ester
Rissman, Anke
O'Mahony, Mary
Neville, Amanda J.
Pierini, Anna
Bergman, Jorieke E. H.
Klungsoyr, Kari
Materna-Kiryluk, Anna
Bielenska, Anna Latos
Carbonell, Clara Cavero
Addor, Marie-Claude
Tucker, David
[J]. REPRODUCTIVE TOXICOLOGY, 2021, 100 : 101 - 108
[4] Congenital anomalies following first-trimester metformin exposure
[J]. Reactions Weekly, 2018, 1709 (1) : 6 - 6
[5] Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy - a cohort linkage study
Garne, E.
Hansen, A. Vinkel
Morris, J.
Jordan, S.
Klungsoyr, K.
Engeland, A.
Tucker, D.
Thayer, D. S.
Davies, G. I.
Andersen, A-M Nybo
Dolk, H.
[J]. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2016, 123 (10) : 1609 - 1618
[6] First Trimester Bleeding and Pregnancy Outcomes: Case-Control Study
Yakistiran, Betul
Yuce, Tuncay
Soylemez, Feride
[J]. INTERNATIONAL JOURNAL OF WOMENS HEALTH AND REPRODUCTION SCIENCES, 2016, 4 (01): : 4 - 7
[7] First trimester pregnancy exposure to modafinil and risk of congenital malformations
Broe, Anne
Damkier, Per
[J]. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2020, 29 : 514 - 514
[8] Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy-a population cohort linkage study.
Garne, E.
Hansen, A., V
Morris, J.
Klungsoyr, K.
Engeland, A.
Jordan, S.
Tucker, D.
Thayer, D. S.
Davies, G., I
Andersen, Nybo A. M.
Dolk, K. H.
[J]. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2015, 24 : 16 - 16
[9] A CASE-CONTROL STUDY TO EVALUATE THE RISK OF CONGENITAL-ANOMALIES AS A RESULT OF ALLYLESTRENOL THERAPY DURING PREGNANCY
CZEIZEL, A
HUISKES, N
[J]. CLINICAL THERAPEUTICS, 1988, 10 (06) : 725 - 739
[10] First-Trimester Pregnancy Exposure to Modafinil and Risk of Congenital Malformations
Damkier, Per
Broe, Anne
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (04): : 374 - 376

← 1 2 3 4 5 →