Evaluating the performance of PI-RADS v2 in the non-academic setting

被引:21
|
作者
Jordan, Eric J. [1 ]
Fiske, Charles [2 ]
Zagoria, Ronald J. [1 ]
Westphalen, Antonio C. [1 ,3 ]
机构
[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, 505 Parnasssus Ave,M-391, San Francisco, CA 94143 USA
[2] RadNet Med Imaging, Walnut Creek, CA USA
[3] Univ Calif San Francisco, Dept Radiol & Biomed Imaging & Urol, San Francisco, CA 94143 USA
关键词
Computed tomography; Angiography; Aortic aneurysm; EVAR; Imaging; PROSTATE-SPECIFIC ANTIGEN; CANCER; BIOPSY; DIAGNOSIS; FUSION; SYSTEM; SCORE;
D O I
10.1007/s00261-017-1169-5
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To evaluate the utility of PI-RADS v2 to diagnose clinically significant prostate cancer (CS-PCa) with magnetic resonance ultrasound (MR/US) fusion-guided prostate biopsies in the non-academic setting. Materials/methods: Retrospective analysis of men whom underwent prostate multiparametric MRI and subsequent MR/US fusion biopsies at a single non-academic center from 11/2014 to 3/2016. Prostate MRIs were performed on a 3-Tesla scanner with a surface body coil. The Prostate Imaging Reporting and Data System (PI-RADS) v2 scoring algorithm was utilized and MR/US fusion biopsies were performed in selected cases. Mixed effect logistic regression analyses and receiver-operating characteristic (ROC) curves were performed on PI-RADS v2 alone and combined with PSA density (PSAD) to predict CS-PCa. Results: 170 patients underwent prostate MRI with 282 PI-RADS lesions. MR/US fusion diagnosed 71 CS-PCa, 33 Gleason score 3+3, and 168 negative. PI-RADS v2 score is a statistically significant predictor of CS-PCa (P < 0.001). For each one-point increase in the overall PI-RADS v2 score, the odds of having CS-PCa increases by 4.2 (95% CI 2.2-8.3). The area under the ROC curve for PI-RADS v2 is 0.69 (95% CI 0.63-0.76) and for PI-RADS v2 + PSAD is 0.76 (95% CI 0.69-0.82), statistically higher than PI-RADS v2 alone (P < 0.001). The rate of CS-PCa was about twice higher in men with high PSAD (>= 0.15) compared to men with low PSAD (< 0.15) when a PI-RADS 4 or 5 lesion was detected (P = 0.005). Conclusion: PI-RADS v2 is a strong predictor of CS-PCa in the non-academic setting and can be further strengthened when utilized with PSA density.
引用
收藏
页码:2725 / 2731
页数:7
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